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Generating optimal control algorithms for artificial pancreases is an intensively researched problem. In this paper the feedback control of type 1 diabetic patients using subcutaneous insulin delivery and subcutaneous glucose monitoring is considered on the high-complexity modified nonlinear diabetic patient Sorensen-model. An acceptable compromise between the model's complexity and the developed control algorithm is certainly the choice of the parametrically varying system (LPV) description. A recently developed nonlinear model-based LPV robust controller is used and its efficiency is tested in quasi in silico mode. Min. 1 week's real data of 30 type 1 diabetic patient (aged between 6-52 years) equipped with Medtronic insulin pump were compared with simulation results of the control algorithm using static and dynamic glucose absorption profiles. The developed framework kept blood glucose level more than 90% of the time inside the 4-8 mmol/l interval (without any recalibration of the algorithm) proving its robustness.

The occurrence of micronuclei proved to be a sensitive biological indicator of clastogenic effects of many chemical and physical agents. The possibility of using the micronucleus technique in radiation protection as an alternative to the traditional chromosomal analysis has recently been followed with increasing interest. This review outlines the main biological and practical aspects of the micronucleus assay and discusses its potential to serve as a rapid and reliable measure of radiation overexposures and hypersensitivities.