1. Diagnostic accuracy of parotid CT for identifying Sjögren's syndrome
- Author
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Zu-yan Zhang, Kai-Yuan Fu, Xu-chen Ma, Yanping Zhao, Deng-gao Liu, and Zhipeng Sun
- Subjects
Adult ,Male ,medicine.medical_specialty ,Sialography ,Diagnostic accuracy ,Computed tomography ,Sensitivity and Specificity ,Asymptomatic ,Atrophy ,stomatognathic system ,medicine ,Humans ,Parotid Gland ,Radiology, Nuclear Medicine and imaging ,Aged ,medicine.diagnostic_test ,Receiver operating characteristic ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,Parotid gland ,Sjogren's Syndrome ,medicine.anatomical_structure ,Female ,Tomography ,Radiology ,medicine.symptom ,Tomography, X-Ray Computed ,business - Abstract
Purpose To evaluate the diagnostic accuracy of computed tomography (CT) of the parotid gland for Sjogren's syndrome in comparison with conventional X-ray sialography. Methods CT scans and X-ray sialography were performed in 34 patients with confirmed Sjogren's syndrome and 22 symptomatic controls without the disease. CT data from 57 asymptomatic controls were included for quantitative analysis. The CT findings of heterogeneity, abnormal diffuse fat tissue deposition, diffuse punctate calcification, swelling or atrophy, nodularity or cystic changes of the parotid gland were analyzed by two independent blinded readers. The correlation between CT and X-ray sialography findings was evaluated. Diagnostic performance and receiver operating characteristics curves were calculated. Results On CT, heterogeneity of the parotid gland was seen in 30/31 (reader 1/reader 2) Sjogren's syndrome patients by the two readers (sensitivity 88.2%/91.2%; specificity 100%/90.9%). Abnormal diffuse fat tissue deposition was seen in 28/28 SS patients by the readers (sensitivity 82.3%/82.3%; specificity 100%/90.9%). Diffuse punctate calcification was seen in 10/12 Sjogren's syndrome patients (sensitivity 29.4%/35.2%; specificity 100%/100%). Stagings of CT findings correlate positively with sialography. The areas under the receiver operating characteristics curves were 0.887 (P = 0.000) and 0.908 (P = 0.000) for the maximum and standard deviation (SD) of the CT value. Conclusions Parotid CT is accurate and reliable in the diagnosis of Sjogren's syndrome. Heterogeneity, abnormal diffuse fat tissue deposition, and diffuse punctate calcification are specific for Sjogren's syndrome. CT attenuation analysis is helpful in diagnosis.
- Published
- 2012
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