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Your search keyword '"Zullo, Alberto"' showing total 9 results
Start Over Author "Zullo, Alberto" Publisher elsevier bv
9 results on '"Zullo, Alberto"'

6. Evidence of epigenetic tags in cardiac fibrosis

Author

Grimaldi, Vincenzo, primary, De Pascale, Maria Rosaria, additional, Zullo, Alberto, additional, Soricelli, Andrea, additional, Infante, Teresa, additional, Mancini, Francesco Paolo, additional, and Napoli, Claudio, additional

Published
2017
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9. Epigenetics and type 1 diabetes: mechanisms and translational applications

Author

Gianfranco Nicoletti, Francesco Donatelli, Francesco Mancini, Linda Sommese, Alberto Zullo, Claudio Napoli, Zullo, Alberto, Sommese, Linda, Nicoletti, Gianfranco, Donatelli, Francesco, Mancini, Francesco P., and Napoli, Claudio

Subjects
0301 basic medicine, Heart disease, 030209 endocrinology & metabolism, Disease, Bioinformatics, Epigenesis, Genetic, Nephropathy, Translational Research, Biomedical, Cell therapy, 03 medical and health sciences, 0302 clinical medicine, Degenerative disease, Risk Factors, Physiology (medical), medicine, Humans, Epigenetics, Type 1 diabetes, business.industry, Medicine (all), Biochemistry (medical), Public Health, Environmental and Occupational Health, General Medicine, medicine.disease, Clinical trial, Diabetes Mellitus, Type 1, 030104 developmental biology, Immunology, business
Abstract

Type 1 diabetes (T1D) is an irreversible degenerative disease with severe complications such as heart disease, nephropathy, neuropathy, and retinopathy. Although exogenous insulin administration is a life-saving therapy, it does not cure the disease. This review addresses the epigenetic mechanisms responsible for the development of T1D and discusses epigenetic-based strategies for prevention and treatment of the disease. We describe novel epigenetic biomarkers for the identification of susceptible individuals and the establishment of innovative therapies with epidrugs and cell therapy to regenerate the lost β-cells. Despite the wealth of promising data regarding the potential benefits of epigenetic tools to reduce the burden of T1D, clinical trials are still very few, and this issue needs to be resolved in the near future.

Published
2017

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