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Case Report: We report a case of a 63-year-old patient with epilepsy treated with vigabatrin, who was seen because of diminished visual acuity. Examination showed a toxic retinopathy with optic nerve pallor and severely constricted visual fields. One year after cessation of the vigabatrin, no change in the perimetric constriction had occurred., Discussion: Ophthalmologists and neurologists need to be aware of the possibility of retinal toxicity due to the use of vigabatrin. It is still unclear as to which ophthalmologic assessment is of the most diagnostic value; however visual field examination covering the peripheral 60 degrees and optical coherence tomography could be most useful for the screening of patients using this agent.

Case Report: A fifty-five year old man complained of diminished visual acuity in his right eye and reported a deep venous thrombosis in his right leg five years ago. Examination showed a central retinal vein occlusion in the right eye. Mutations in the factor V gene and prothrombin gene were found in a thrombophilia study. The patient was anticoagulated and no laser photocoagulation was required., Discussion: Various coagulation disorders induced by genetic mutations are often associated with an increased risk for retinal vein occlusion although there are no statistically significant associations reported in the literature.

Case Report: We report the case of a diabetic twenty-five-year-old male with an asymptomatic bull's eye maculopathy in the left eye who was diagnosed by chance in a routine examination. The electrophysiological test showed a right eye photopic electroretinogram at the lower limit of normality., Discussion: In the presence of a bull's eye maculopathy we must rule out several pathologies like degenerative diseases, drug toxicity, previous trauma and infectious -- inflammatory diseases. Electrophysiology as well as family and personal history can help us to differentiate between several diseases though in our case the cause was unknown.

Case Report: A thirty year-old-woman that had received radiotherapy three years before for a frontal glyoma consulted because of diminished visual acuity in her left eye. Examination showed a proliferative radiation retinopathy in the left eye and non-proliferative radiation retinopathy in the right eye that was confirmed by fluorescein angiography. The patient was treated with panretinal photocoagulation, and her visual acuity remained stable., Discussion: Patients receiving cranial or neck radiotherapy should be followed for long periods of time because radiation retinopathy may appear many years after the treatment. Follow-up may permit early diagnosis of ischemic radiation retinopathy that can benefit from laser photocoagulation.