1. Effect of polymyxin B-containing regimens on renal function for the treatment of carbapenem-resistant Enterobacteriacea mediastinitis.
- Author
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Abboud CS, Rao GG, Souza EE, Zavascki AP, and Kiffer C
- Subjects
- Acute Kidney Injury chemically induced, Aminoglycosides therapeutic use, Carbapenems pharmacology, Enterobacteriaceae Infections mortality, Female, Humans, Kaplan-Meier Estimate, Male, Mediastinitis mortality, Microbial Sensitivity Tests, Retrospective Studies, Risk Assessment, Statistics, Nonparametric, Treatment Outcome, beta-Lactam Resistance drug effects, Anti-Bacterial Agents therapeutic use, Enterobacteriaceae Infections drug therapy, Kidney drug effects, Mediastinitis drug therapy, Mediastinitis microbiology, Polymyxin B therapeutic use
- Abstract
A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3-14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6-42) days in the polymyxin with other antimicrobial combinations group (p=0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction., (Copyright © 2017 Sociedade Brasileira de Infectologia. Published by Elsevier Editora Ltda. All rights reserved.)
- Published
- 2018
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