1. Lixisenatida en pacientes con diabetes tipo 2 y obesidad: más allá del control glucémico
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Silvia Maraver-Selfa, Francisco J. Tinahones, Isabel Mancha-Doblas, Miguel Quesada-Charneco, M. Mar Roca-Rodriguez, María Teresa Muros de Fuentes, Gonzalo Piedrola-Maroto, [Roca-Rodríguez,MM] UGC de Endocrinología y Nutrición, Hospital Universitario Puerta del Mar, Cádiz, España. [Muros de Fuentes,MT, Piédrola-Maroto,G] UGC de Endocrinología y Nutrición, Hospital Virgen de las Nieves, Granada, España. [Quesada-Charneco,M] UGC de Endocrinología y Nutrición, Hospital San Cecilio, Granada, España. [Maraver-Selfa,S, Tinahones,FJ, Mancha-Doblas,I] UGC de Endocrinología y Nutrición, Hospital Clínico Universitario Virgen de la Victoria. Hospital Regional Universitario, Málaga, España. [Tinahones,FJ] Instituto de Investigación Biomédica de Málaga (IBIMA), Complejo Hospitalario de Málaga (Virgen de la Victoria)/Universidad de Málaga, CIBER Pathophysiology of Obesity and Nutrition (CB06/03), Málaga, España., and Este trabajo ha sido financiado, en parte, con ayudas del Instituto de Salud Carlos III (PI15/01114) y de la Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía (PI11-CTS-8181). Este estudio ha sido cofinanciado con fondos FEDER.
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Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Cardiovascular Agents::Antihypertensive Agents [Medical Subject Headings] ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Prospective Studies [Medical Subject Headings] ,Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index [Medical Subject Headings] ,Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose [Medical Subject Headings] ,Obesidad ,Lixisenatide ,030209 endocrinology & metabolism ,Diabetes tipo2 ,Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight [Medical Subject Headings] ,Chemicals and Drugs::Lipids [Medical Subject Headings] ,Análogos de GLP-1 ,Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [Medical Subject Headings] ,Diabetes tipo 2 ,Metabolic control ,Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings] ,03 medical and health sciences ,Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings] ,0302 clinical medicine ,Lixisenatida ,Phenomena and Processes::Circulatory and Respiratory Physiological Phenomena::Cardiovascular Physiological Phenomena::Hemodynamics::Blood Pressure [Medical Subject Headings] ,Control metabólico ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Body Constitution::Body Weights and Measures::Body Size::Waist Circumference [Medical Subject Headings] ,030212 general & internal medicine ,Obesity ,Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings] ,Chemicals and Drugs::Lipids::Glycerides::Triglycerides [Medical Subject Headings] ,Medicine(all) ,lcsh:R5-920 ,Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Diagnostic Techniques, Cardiovascular::Blood Pressure Determination [Medical Subject Headings] ,Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL::Cholesterol, LDL [Medical Subject Headings] ,Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings] ,Type 2 diabetes ,General Medicine ,Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Glycoside Hydrolases::Amylases [Medical Subject Headings] ,Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity [Medical Subject Headings] ,Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Fasting [Medical Subject Headings] ,Check Tags::Female [Medical Subject Headings] ,lcsh:Medicine (General) ,Family Practice ,GLP-1 ,Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose::Blood Glucose [Medical Subject Headings] - Abstract
To evaluate tolerance to lixisenatide and its effects on weight and metabolic control in type2 diabetes and obese patients. DESIGN: Prospective study. SETTING: Endocrinology clinics in Almeria, Granada and Malaga. PARTICIPANTS: Patients with type2 diabetes and obesity. INTERVENTIONS: Response and tolerance to lixisenatide treatment. MAIN MEASUREMENTS: Clinical and analytical data of the subjects were evaluated at baseline and after treatment. RESULTS: The study included 104 patients (51% women) with type2 diabetes and obesity (Almeria 18.3%; Granada 40.4%; Malaga 41.3%). The mean age was 58.4±10.5years, and the mean duration of diabetes was 11.2±6.7years. The patients were re-evaluated at 3.8±1.6months after treatment with lixisenatide. Significant improvements were found in weight (P
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