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Your search keyword '"Navarro Risueño, Ferran"' showing total 2 results
Start Over Author "Navarro Risueño, Ferran" Publisher elsevier espana
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2. [Interpretive reading of the antibiogram of enterobacteria].

Author

Navarro Risueño F, Miró Cardona E, and Mirelis Otero B

Subjects
Acetyltransferases antagonists & inhibitors, Acetyltransferases classification, Acetyltransferases genetics, Acetyltransferases physiology, Anti-Bacterial Agents classification, Anti-Bacterial Agents metabolism, Bacterial Proteins antagonists & inhibitors, Bacterial Proteins classification, Bacterial Proteins genetics, Chromosomes, Bacterial genetics, DNA Gyrase genetics, DNA Topoisomerases genetics, Enterobacteriaceae enzymology, Enterobacteriaceae genetics, Enzyme Inhibitors pharmacology, Gene Expression Regulation, Bacterial, Kanamycin Kinase antagonists & inhibitors, Kanamycin Kinase classification, Kanamycin Kinase genetics, Kanamycin Kinase physiology, Phenotype, R Factors, Substrate Specificity, beta-Lactamase Inhibitors, beta-Lactamases classification, beta-Lactamases genetics, beta-Lactamases physiology, Anti-Bacterial Agents pharmacology, Bacterial Proteins physiology, Drug Resistance, Multiple, Bacterial genetics, Enterobacteriaceae drug effects, Microbial Sensitivity Tests
Abstract

Many of the resistance mechanisms of enterobacteria to antimicrobial agents are well understood; nevertheless several aspects remain unsolved, particularly with regard to prediction of clinical response. The resistance pattern observed in the antibiogram of a specific organism should be the sum of the natural resistance pattern, characteristic of the species, plus the acquired resistance. In enterobacteria the principal mechanism of resistance to beta lactams and aminoglycosides is enzyme production, Each enzyme recognizes one or more specific beta lactam or aminoglycoside, as a substrate. This translates as a specific resistance phenotype that allows one to infer the enzyme(s) implicated. Enzyme resistance is not, however, the only mechanism of resistance to these agents; often the pattern observed is multifactorial. Resistance to quinolones is due to point and sequence mutations which may be selected by initially active fluoroquinolones and cause a stepwise increase of resistance.

Published
2002
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