1. Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics.
- Author
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Schüring AN, Schulte N, Kelsch R, Röpke A, Kiesel L, and Götte M
- Subjects
- Adult, Biopsy, Cell Differentiation physiology, Cell Lineage physiology, Female, Humans, Stromal Cells cytology, Adult Stem Cells cytology, Cell Separation, Endometrium cytology, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells cytology
- Abstract
Endometrial cell clones derived from in vitro cultured purified stromal cells obtained by endometrial biopsy display characteristic stem cell features, including clonality; long-term culturing properties; multilineage differentiation potential; expression of CD146, CD105, CD90, CD73, MSI1, NOTCH1, and SOX2; and absence of CD34 and CD14 expression. We conclude that adult stem cells are present in endometrial biopsies performed in a routine clinical setting, offering new large-scale approaches for future research, diagnostics, and therapies involving adult stem cells., (Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
- Published
- 2011
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