1. Toxicological evaluation of cigarettes with two banded cigarette paper technologies.
- Author
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Theophilus EH, Pence DH, Meckley DR, Keith Shreve W, Ayres PH, Bombick BR, Borgerding MF, Garner CD, and Swauger JE
- Subjects
- Administration, Inhalation, Administration, Topical, Animals, CHO Cells drug effects, CHO Cells metabolism, CHO Cells pathology, Cell Survival drug effects, Cricetinae, Cricetulus, Dose-Response Relationship, Drug, Female, Immunosuppressive Agents toxicity, Male, Mice, Mice, Inbred SENCAR, Neutral Red, Rats, Rats, Sprague-Dawley, Salmonella typhimurium drug effects, Salmonella typhimurium genetics, Sister Chromatid Exchange drug effects, Sister Chromatid Exchange genetics, Skin Neoplasms chemically induced, Skin Neoplasms pathology, Smoke analysis, Tars chemistry, Tars toxicity, Toxicity Tests, Tobacco Products, Paper, Smoke adverse effects, Technology, Tobacco Industry methods
- Abstract
A tiered testing strategy has been employed to evaluate the potential of tobacco processes, ingredients, or technological developments to change the biological activity resulting from burning cigarette tobacco. The strategy is based on comparative chemical and biological testing. The introduction of banded cigarette papers in cigarettes to meet New York state "Fire Safety Standards for Cigarettes" constitutes an example of a technological development evaluated utilizing this tiered testing strategy that included a comparison of the chemical and biological effects of cigarettes with and without the banded cigarette paper technologies (BCPT) (representative of current marketed technologies). Specific testing included mainstream cigarette smoke chemistry studies; in vitro studies included genotoxicity (Ames and sister chromatid exchange) and cytotoxicity studies (neutral red); in vivo studies included a 13-week inhalation study in Sprague-Dawley rats and a 30-week dermal tumor promotion study in SENCAR mice. Collectively, data indicated that cigarettes with and without BCPT had a similar toxicological profile in this test battery.
- Published
- 2007
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