1. Gastric Cancer Risk in Patients with Helicobacter pylori Infection and Following Its Eradication.
- Author
-
Rugge M
- Subjects
- Gastric Mucosa microbiology, Helicobacter Infections complications, Helicobacter Infections pathology, Humans, Risk Factors, Stomach Neoplasms pathology, Anti-Bacterial Agents therapeutic use, Gastric Mucosa pathology, Helicobacter Infections drug therapy, Helicobacter pylori, Stomach Neoplasms microbiology
- Abstract
As Helicobacter pylori is a first-class carcinogen, eradication of the infection would be expected to be a beneficial measure for the (primary) prevention of gastric cancer. Given the natural history of gastric cancer, it is plausible that eradication before gastric atrophy sets in offers the best chance for cancer risk reduction. The beneficial effects of eradication may, nevertheless, still be achievable in more advanced disease. The reversibility of inflammatory lesions has been supported by undeniable evidence; the regression of mucosal atrophy/metaplasia has also been confirmed by several recent histologic studies., (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Published
- 2015
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