1. Long-Term Plasticity Mediated by mGluR1 at a Retinal Reciprocal Synapse
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Henrique von Gersdorff, Jozsef Vigh, Court Hull, and Geng Lin Li
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Patch-Clamp Techniques ,Neuroscience(all) ,Biology ,Receptors, Metabotropic Glutamate ,Retina ,Article ,gamma-Aminobutyric acid ,Synapse ,Organ Culture Techniques ,Receptors, GABA ,Goldfish ,Metaplasticity ,medicine ,Animals ,gamma-Aminobutyric Acid ,Neuronal Plasticity ,General Neuroscience ,Glutamate receptor ,medicine.anatomical_structure ,Synapses ,Synaptic plasticity ,Silent synapse ,Metabotropic glutamate receptor 1 ,Neuroscience ,medicine.drug - Abstract
SummaryThe flow of information across the retina is controlled by reciprocal synapses between bipolar cell terminals and amacrine cells. However, the synaptic delays and properties of plasticity at these synapses are not known. Here we report that glutamate release from goldfish Mb-type bipolar cell terminals can trigger fast (delay of 2–3 ms) and transient GABAA IPSCs and a much slower and more sustained GABAC feedback. Synaptically released glutamate activated mGluR1 receptors on amacrine cells and, depending on the strength of presynaptic activity, potentiated subsequent feedback. This poststimulus enhancement of GABAergic feedback lasted for up to 10 min. This form of mGluR1-mediated long-term synaptic plasticity may provide retinal reciprocal synapses with adaptive capabilities.
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