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ObjectiveTo investigate the influence of implant design on the change in the natural frequency of bone-implant system during osseointegration by means of a modal 3D finite element analysis.MethodsSix implants were considered. Solid models were obtained by means of reverse engineering techniques. The mandibular bone geometry was built-up from a CT scan dataset through image segmentation. Each implant was virtually implanted in the mandibular bone. Two different models have been considered, differing in the free length of the mandibular branch (‘long branch’ and ‘short branch’) in order to simulate the variability of boundary conditions when performing vibrometric analyses. Modal analyses were carried out for each model, and the first three resonance frequencies were assessed with the respective vibration modes.ResultsWith reference to the ‘long branch’ model, the first three modes of vibration are whole bone vibration with minimum displacement of the implant relative to bone, with the exception of the initial condition (1% bone maturation) where the implant is not osseointegrated. By contrast, implant displacements become relevant in the ‘short branch’ model, unless osseointegration level is beyond 20%. The difference between resonance frequency at whole bone maturation and resonance frequency at 1% bone maturation remained lower than 6.5% for all modes, with the exception of the third mode of vibration in the ‘D’ implant where this difference reached 9.7%. With reference to the ‘short branch’, considering the first mode of vibration, 61–68% of the frequency increase was achieved at 10% osseointegration; 72–79% was achieved at 20%; 89–93% was achieved at 50% osseointegration. The pattern of the natural frequency versus the osseointegration level is similar among different modes of vibration.SignificanceResonance frequencies and their trends towards osseointegration level may differ between implant designs, and in different boundary conditions that are related to implant position inside the mandible; tapered implants are the most sensitive to bone maturation levels, small implants have very little sensitivity. Resonance frequencies are less sensitive to bone maturation level beyond 50%.

Introduction This review analyzes the increasing role of magnetic resonance imaging (MRI) in dentistry and its relevance in endodontics. Limits and new strategies to develop MRI protocols for endodontic purposes are reported and discussed. Methods Eligible studies were identified by searching the PubMed databases. Only original articles on dental structures, anatomy, and endodontics investigated by in vitro and in vivo MRI were included in this review. Original articles on MRI in dentistry not concerning anatomy and endodontics were excluded. Results All the consulted studies showed well-defined images of pathological conditions such as caries and microcracks. The enhanced contrast of pulp provided a high-quality reproduction of the tooth shape and root canal in vitro and in vivo. Assessment of periapical lesions is possible even without the use of contrast medium. Conclusions MRI is a nonionizing technique characterized by high tissue contrast and high image resolution of soft tissues; it could be considered a valid and safe diagnostic investigation in endodontics because of its potential to identify pulp tissues, define root canal shape, and locate periapical lesions.

The aim of the present study was to investigate the impact of ambient temperature on the life span of nickel-titanium (NiTi) files.Cyclic fatigue testing of NiTi instruments was performed in a stainless steel artificial canal. During the experiment, 4 different temperatures (0°C, 20°C, 35°C, and 39°C) were used in a thermostatic bath controlled using electronic and infrared controls. Eighty R25 Reciproc Blue (VDW, Munich, Germany) and 80 R25 Reciproc (VDW) instruments were reciprocated in the artificial canal until fracture occurred, and the time to fracture and the length of the fractured fragment were recorded. The phase transformation temperature for 3 instruments of each type was analyzed by differential scanning calorimetry. One-way analysis of variance and Bonferroni tests were used to statistically analyze the data at a 5% significance level (P .05).Reciproc Blue instruments were significantly more resistant to cyclic fatigue than Reciproc at all the temperatures tested (P .05). Fatigue resistance was proportionally higher as the environmental temperature decreased (0°C 20°C35°C 39°C). No significant difference was registered for the length of the fractured fragment of both instruments tested at all temperatures tested (P .05).Blue alloy significantly increases the cyclic fatigue resistance of Reciproc files compared with M-Wire alloy. Temperature significantly affects the life span of NiTi files. When the ambient temperature increases between 0°C and 35°C, the fatigue resistance of the files statistically decreases.

Introduction The aim of this study was to compare the accuracy of 2 electronic apex locators (EALs), Apex ID (SybronEndo, Glendora, CA) and Root ZX (J. Morita, Tokyo, Japan), by means of micro–computed tomographic (micro-CT) imaging and to determine anatomic variations that may affect their accuracy. Methods The root canal length (RCL) and working length (WL) of 33 single-rooted premolars were measured using a visual method, 3-dimensional micro-CT reconstructions, and 2 different EALs. Two different measurements were recorded for each EAL: at the "APEX/0.0" mark and at the "0.5" mark. The WL was determined using 2 different methods: method 1: at the "0.5 mark" of the apex locator and method 2: subtracting 0.5 mm from the "APEX/0.0" mark. The precision of measurements was compared with those recorded by micro-CT imaging. Apical foramen (AF) position and diameter, apical constriction (AC) diameter, distance between the AC and the AF, and the presence/absence of accessory canals were recorded from the micro-CT scans, and their correlation to the accuracy of EALs was determined. Results There was no statistically significant difference in the RCL measurements by any of the different methods. There was a statistically significant difference in the WL recorded by micro-CT imaging compared with those by the visual method and at the "APEX/0.0 mark" − 0.5 mm ( P = .031). There was no difference in the measurements acquired by any of the EALs. The "APEX/0.0 mark" − 0.5 mm was less accurate than the "0.5" mark. However, the results were not statistically significant ( P > .05). The position of the AF and the AC–AF distance affected the accuracy of the RCL ( P = .003) and the "0.5" mark ( P = .013). Conclusions Root ZX and Apex ID are equally precise in determining the RCL and WL. The "0.5" mark can be used to determine the WL with high precision. Some anatomic variations may influence the accuracy of EALs.

Introduction:Thepurposeofthisstudywastoevaluate the cyclic fatigue resistance of 3 different nickeltitanium reciprocating instruments. Methods: A total of 45 nickel-titanium instruments were tested and divided into 3 experimental groups (n = 15): group 1, WaveOne Primary instruments; group 2, Reciproc R25 instruments; and group 3, Twisted File (TF) Adaptive M-L1 instruments. The instruments were then subjected to cyclic fatigue test on a static model consisting of a metal block with a simulated canal with 60 angle of curvature and a 5-mm radius of curvature. WaveOne Primary, Reciproc R25, and TF Adaptive instruments were activated by using their proprietary movements, WaveOne ALL, Reciproc ALL, and TF Adaptive, respectively. All instruments were activated until fracture occurred, and the time to fracture was recorded visually for each file with a 1/100-second chronometer. Mean number of cycles to failure and standard deviations were calculated for each group, and data were statistically analyzed (P < .05). Instruments were also observed through scanning electron microscopy to evaluate type offracture.Results:CyclicfatigueresistanceofReciproc R25 and TF Adaptive M-L1 was significantly higher than that of WaveOne Primary (P = .009 and P = .002, respectively). The results showed no statistically significant difference between TF Adaptive M-L1 and Reciproc R25 (P = .686). Analysis of the fractured portion under scanning electron microscopy indicated that all instruments showed morphologic characteristics of ductile fracture that were due to accumulation of metal fatigue. Conclusions: No statistically significant differences were found between the instruments tested except for WaveOne Primary, which showed the lowest resistance to cyclic fatigue. (J Endod 2015;41:913‐915)

Tumor development and progression are strongly linked to inflammation and macrophage infiltration is a major component of the inflammatory reactions associated with neoplasia. Plasticity is a hallmark of mononuclear phagocytes, which undergo polarized diverse forms of activation. Metabolic adaptation is a key component of macrophage plasticity and polarization, instrumental to their function in homeostasis, immunity and inflammation. Tumor-associated macrophages (TAM) and related immature myeloid suppressor cells generally have properties of an M2-like population. TAM produce growth factors, have immunoregulatory and immunosuppressive activity, stimulate angiogenesis and provide tissue remodeling, invasion and metastasis. Thus, TAM are a key component of cancer-promoting inflammatory reactions.