35 results on '"Mertens, Koen"'
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2. Factor VIII–driven changes in activated factor IX explored by hydrogen-deuterium exchange mass spectrometry
3. Unique surface‐exposed hydrophobic residues in the C1 domain of factor VIII contribute to cofactor function and von Willebrand factor binding
4. Quantitative phosphoproteomics unveils temporal dynamics of thrombin signaling in human endothelial cells
5. Analysis of the storage and secretion of von Willebrand factor in blood outgrowth endothelial cells derived from patients with von Willebrand disease
6. Factor VIII C1 domain residues Lys 2092 and Phe 2093 contribute to membrane binding and cofactor activity
7. Association between beta2-glycoprotein I plasma levels and the risk of myocardial infarction in older men
8. Intracellular cotrafficking of factor VIII and von Willebrand factor type 2N variants to storage organelles
9. Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells
10. LDL receptor cooperates with LDL receptor–related protein in regulating plasma levels of coagulation factor VIII in vivo
11. Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor–related protein deficiency
12. Two classes of germline genes both derived from the VH1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII
13. 3-Dimensional structure of membrane-bound coagulation factor VIII: modeling of the factor VIII heterodimer within a 3-dimensional density map derived by electron crystallography
14. Functional mapping of anti–factor IX inhibitors developed in patients with severe hemophilia B
15. Multiple VH genes are used to assemble human antibodies directed toward the A3-C1 domains of factor VIII
16. Activation of factor IX zymogen results in exposure of a binding site for low-density lipoprotein receptor–related protein
17. The Munc18-2 1247-1G>C splice-site variant exhibits limited interference on platelet degranulation
18. Whole Exome Sequencing and Extended Thrombophilia Testing in Patients with Venous Thromboembolism
19. Cell-Surface Proteomics to Unravel Cytokine-Induced Endothelial Activation
20. Von Willebrand Factor Protects Factor VIII from Rapid Endocytosis Via LDL Receptor-Related Protein By Blocking the Initial Rate-Limiting Cell Surface Binding Step of Factor VIII
21. Factors VIII and V swap fatty feet
22. The N-Terminal Amino Acid Residues Ser764 and Lys773 of the D' Domain of Von Willebrand Factor Contribute to Factor VIII Binding
23. The Role of Factor VIII C Domains in Sorting to Weibel-Palade Bodies
24. Modification of An Interactive Surface in the C1 Domain Reduces Immune Responses to FVIII in a Mouse Model of Hemophilia A
25. Differential Anticoagulant Effects of Protein S on Vascular Cells and Platelets.
26. Decreased beta2-Glycoprotein I Plasma Levels as a Risk Factor for Myocardial Infarction in Men.
27. Factor VIII C1 Domain Residues 2092–2093 Participate in Membrane Binding
28. Antiphospholipid Antibodies with LAC Activity That Bind beta2-Glycoprotein I Cause Increased Resistance Against Activated Protein C.
29. PEGylation or Polysialylation Reduces FVIII Binding to LRP Resulting in Prolonged Half-Life in Murine Models.
30. Somatic Mutations in Factor VIII Inhibitors Determine Their Factor VIII Binding and Inhibitory Properties.
31. Effective Factor VIII Endocytosis Is under Conformational Control of von Willebrand Factor.
32. LDL Receptor Mediates Effective Endocytosis of Activated Factor V.
33. The Effect of von Willebrand Factor Normandy Mutations on Intracellular Co-Trafficking of Factor VIII to Storage Organelles.
34. Role of Low Density Lipoprotein Receptor in the Clearance of Coagulation Factor VIII In Vivo.
35. The Life Cycle of Coagulation Factor VIII in View of Its Structure and Function
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