Search

Your search keyword '"Mohammad Kamran"' showing total 32 results
Start Over Author "Mohammad Kamran" Publisher elsevier inc.
32 results on '"Mohammad Kamran"'

2. Genome-wide profiling of circulatory microRNAs associated with cognition and dementia

Author

Amber Yaqub, Michelle M.J. Mens, Jaco M. Klap, Gerrit Jan Weverling, Paul Klatser, Just P.J. Brakenhoff, Gennady V. Roshchupkin, Mohammad Kamran Ikram, Mohsen Ghanbari, Mohammad Arfan Ikram, Epidemiology, Radiology & Nuclear Medicine, and Neurology

Subjects
Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, SDG 3 - Good Health and Well-being, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology
Abstract

Introduction: MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression. Their role in the pathophysiology of dementia and potential as biomarkers remains undetermined. Methods: We conducted a single- (one-by-one) and multi-marker (joint) analysis to identify well-expressed circulating miRNAs in plasma (total = 591) associated with general cognition and incident dementia, for 1615 participants of the population-based Rotterdam Study. Results: During single-marker analysis, 47 miRNAs were nominally (P ≤.05) associated with cognition and 18 miRNAs were nominally associated with incident dementia, after adjustment for potential confounders. Three miRNAs were common between cognition and dementia (miR-4539, miR-372-3p, and miR-566), with multi-marker analysis revealing another common miRNA (miR-7106-5p). In silico analysis of these four common miRNAs led to several putative target genes expressed in the brain, highlighting the mitogen-activated protein kinase signaling pathway. Discussion: We provide population-based evidence on the relationship between circulatory miRNAs with cognition and dementia, including four common miRNAs that may elucidate downstream mechanisms. HIGHLIGHTS: MicroRNAs (miRNAs) are involved in the (dys)function of the central nervous system. Four circulating miRNAs in plasma are associated with cognition and incident dementia. Several predicted target genes of these four miRNAs are expressed in the brain. These four miRNAs may be linked to pathways underlying dementia. Although miRNAs are promising biomarkers, experimental validation remains essential.

Published
2023

Catalog

Books, media, physical & digital resources
See catalog results