1. Expanding the Boundaries of Embryonic Stem Cells
- Author
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Nissim Benvenisty, Oded Kopper, and Uri Ben-David
- Subjects
Directed differentiation ,embryonic structures ,Genetics ,Animals ,Humans ,Molecular Medicine ,Cell Differentiation ,Epigenetics ,Cell Biology ,Biology ,Embryonic stem cell ,Neuroscience ,Embryonic Stem Cells - Abstract
The boundaries of embryonic stem cell (ESC) research have extended considerably in recent years in several important ways. Alongside a deeper understanding of the pluripotent state, ESCs have been successfully integrated into various fields, such as genomics, epigenetics, and disease modeling. Significant progress in cell fate control has pushed directed differentiation and tissue engineering further than ever before and promoted clinical trials. The geographical distribution of research activity has also expanded, especially for human ESCs. This review outlines these developments and future challenges that remain.
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