1. Regulation of cGAS and STING signaling during inflammation and infection.
- Author
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Chauvin SD, Stinson WA, Platt DJ, Poddar S, and Miner JJ
- Subjects
- Humans, Inflammation metabolism, DNA metabolism, Cytosol metabolism, Immunity, Innate, Signal Transduction physiology, Nucleotidyltransferases genetics, Nucleotidyltransferases metabolism
- Abstract
Stimulator of interferon genes (STING) is a sensor of cyclic dinucleotides including cyclic GMP-AMP, which is produced by cyclic GMP-AMP synthase (cGAS) in response to cytosolic DNA. The cGAS-STING signaling pathway regulates both innate and adaptive immune responses, as well as fundamental cellular functions such as autophagy, senescence, and apoptosis. Mutations leading to constitutive activation of STING cause devastating human diseases. Thus, the cGAS-STING pathway is of great interest because of its role in diverse cellular processes and because of the potential therapeutic implications of targeting cGAS and STING. Here, we review molecular and cellular mechanisms of STING signaling, and we propose a framework for understanding the immunological and other cellular functions of STING in the context of disease., Competing Interests: Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article., (Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.) more...
- Published
- 2023
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