1. Determinants of health-related quality of life in the postpartum period after obstetric complications
- Author
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A.J. Gerard Jansen, Marie-Louise Essink-Bot, Ben W.J. Mol, Babette W. Prick, Dick J. van Rhenen, Kim E. Boers, Corine M. Koopmans, Sicco A. Scherjon, Johannes J. Duvekot, Mariëlle G. van Pampus, Denise Bijlenga, Reproductive Origins of Adult Health and Disease (ROAHD), Obstetrics & Gynecology, Amsterdam Public Health, Public and occupational health, and Obstetrics and Gynaecology
- Subjects
Adult ,Gestational hypertension ,medicine.medical_specialty ,IMPACT ,Health-related quality of life ,Birth weight ,Population ,TERM ,law.invention ,Young Adult ,DELIVERY ,HEMORRHAGE ,Obstetric labor complications ,Randomized controlled trial ,law ,medicine ,Humans ,education ,reproductive and urinary physiology ,Pregnancy ,education.field_of_study ,Cesarean Section ,Obstetrics ,Vaginal delivery ,business.industry ,WOMEN ,Obstetrics and Gynecology ,Postpartum period ,medicine.disease ,BIRTH-WEIGHT ,humanities ,Obstetric labor complication ,PREECLAMPSIA ,PREGNANCY ,Socioeconomic Factors ,Pregnancy complications ,Reproductive Medicine ,INCONTINENCE ,Quality of Life ,Regression Analysis ,Female ,TRIAL ,business - Abstract
Objective: To determine the influence of socio-demographic, clinical parameters and obstetric complications on postpartum health-related quality of life (HRQoL).Study design: We used data of three randomized controlled trials to investigate HRQoL determinants in women after an obstetric complication. The DIGITAT and HYPITAT trials compared induction of labor and expectant management in women with intra-uterine growth restriction (IUGR) and hypertensive disorders. The WOMB trial randomized anemic women after postpartum hemorrhage to red blood cell transfusion or expectant management. The HRQoL-measure Short-Form36 was completed at six weeks postpartum. Multivariable analyses were used to identify which parameters affected the Short-Form36 physical component score (PCS) and mental component score (MCS).Results: HRQoL analyses included 1391 women (60%) of the 2310 trial participants. HYPITAT and DIGITAT participants had significantly lower MCS than WOMB participants. In multivariable analysis, PCS after elective and emergency cesarean section was 5-6 points lower than after vaginal delivery. Gestational hypertension, neonatal admission and delivery in an academic hospital had a small negative effect on PCS. No effect was found for randomization status, maternal age, BMI, country of birth, education, parity, induction of labor, analgesics, birth weight, perineal laceration, delivery of placenta, postpartum hemorrhage, congenital anomaly, urinary tract infection, thromboembolic event or endometritis. MCS was influenced only mildly by these parameters.Conclusions: IUGR and hypertensive disorders lead to lower HRQoL scores postpartum than PPH. In a heterogeneous obstetric population, only mode of delivery by cesarean section has a profound, negative impact, on physical HRQoL (PCS). No profound impacts on MCS were detected. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
- Published
- 2015