1. Electrophysiological evidence of altered facial expressions recognition in Alzheimer's disease: A comprehensive ERP study
- Author
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Bahar Güntekin, Görsev Yener, Ezgi Fide, Derya Durusu Emek-Savaş, Tuba Aktürk, and Lutfu Hanoglu
- Subjects
Male ,medicine.medical_specialty ,Reduced amygdala volume ,genetic structures ,media_common.quotation_subject ,Disease ,Neuropsychological Tests ,Audiology ,ERP N230 ,Alzheimer's Disease ,behavioral disciplines and activities ,050105 experimental psychology ,ERP N170 ,03 medical and health sciences ,0302 clinical medicine ,Alzheimer Disease ,ERP VPP ,Physiology (medical) ,Perception ,medicine ,Humans ,0501 psychology and cognitive sciences ,Latency (engineering) ,Aged ,media_common ,Aged, 80 and over ,Facial expression ,05 social sciences ,ERP P100 ,Sensory Systems ,Facial Expression ,Electrophysiology ,Amplitude ,Neurology ,Categorization ,Emotion Recognition ,Evoked Potentials, Visual ,Female ,Neurology (clinical) ,Psychology ,Facial Recognition ,Photic Stimulation ,030217 neurology & neurosurgery - Abstract
Objectives: The present study aims to evaluate the amplitude and latency of event-related potentials (ERPs) P100, N170, VPP and N230 in individuals with Alzheimer's disease (AD) compared to healthy elderly controls, using a passive viewing task of emotional facial expressions. Methods: Twenty-four individuals with mild to moderate AD and 23 demographically matched healthy elderly controls were included in the study. ERP P100, N170, VPP and N230 amplitude and latency values were compared between groups. Results: The categorization of emotional facial expressions was intact; yet, increased P100 amplitude and latency, decreased N170 amplitude, and increased VPP amplitude were observed in AD compared to controls. Increased N230 amplitude and latency were observed in response to angry expressions, while neutral expressions elicited decreased amplitude and latency. Conclusions: Increased P100 amplitude and latency may reflect reduced amygdala volume and disruptions in the visual system, while decreased N170 and increased VPP amplitudes may reflect impaired perceptual processing, mitigated by a greater involvement of prefrontal areas for task performance in AD. Significance: This study is the first to report a complex pattern of ERPs to emotional facial expressions in individuals with AD. (C) 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.
- Published
- 2019