1. Sensory processing deficiencies in patients with borderline personality disorder who experience auditory verbal hallucinations
- Author
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Ingmar H.A. Franken, Mark van der Gaag, Iris E. C. Sommer, Mathijs Deen, Frederik M. van der Veen, Maria B. A. Niemantsverdriet, Christina W. Slotema, Clinical Psychology, APH - Mental Health, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Clinical Cognitive Neuropsychiatry Research Program (CCNP), Movement Disorder (MD), Department of Psychology, Education and Child Studies, and Erasmus MC other
- Subjects
Male ,SYMPTOMS ,Hallucinations ,Mismatch negativity ,medicine.medical_treatment ,Evoked potential ,Audiology ,0302 clinical medicine ,Borderline Personality Disorder ,SCHIZOPHRENIA ,Medicine ,Borderline personality disorder ,Sensory gating ,Electroencephalography ,BIPOLAR DISORDER ,Middle Aged ,Psychiatry and Mental health ,medicine.anatomical_structure ,Schizophrenia ,Sensation Disorders ,Evoked Potentials, Auditory ,Female ,CLOZAPINE ,Event-related potentials ,Adult ,Psychosis ,medicine.medical_specialty ,Sensory processing ,MISMATCH NEGATIVITY MMN ,behavioral disciplines and activities ,03 medical and health sciences ,Event-related potential ,Humans ,Bipolar disorder ,Biological Psychiatry ,METAANALYSIS ,Auditory Cortex ,business.industry ,GATING DEFICIT ,P50 ,medicine.disease ,SIMILARITIES ,030227 psychiatry ,SCHIZOTYPAL ,P50 SUPPRESSION DEFICITS ,business ,030217 neurology & neurosurgery - Abstract
Auditory verbal hallucinations (AVH) are common in patients with borderline personality disorder (BPD). We examined two candidate mechanisms of AVH in patients with BPD, suggested to underlie sensory processing systems that contribute to psychotic symptoms in patients with schizophrenia; sensory gating (P50 ratio and P50 difference) and change detection (mismatch negativity; MMN). Via electroencephalographic recordings P50 amplitude, P50 ratio, P50 difference and MMN amplitude were compared between 23 borderline patients with and 25 without AVH, and 26 healthy controls. Borderline patients with AVH had a significantly lower P50 difference compared with healthy controls, whereas no difference was found between borderline patients without AVH and healthy controls. The groups did not differ on MMN amplitude.The impaired sensory gating in patients with borderline personality disorder who experience AVH implies that P50 sensory gating deficiencies may underlie psychotic vulnerability in this specific patient group. Patients with borderline personality disorder with or without AVH did not have problems with auditory change detection. This may explain why they are spared from the poor outcome associated with negative symptoms and symptoms of disorganization in patients with chronic schizophrenia.
- Published
- 2019