1. Neurological condition in 42-month-old children in relation to pre- and postnatal exposure to polychlorinated biphenyls and dioxins
- Author
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Svati Patandin, Vaclav Fidler, Eric Boersma, Nynke Weisglas-Kuperus, Bert C.L. Touwen, Caren I. Lanting, Pieter J J Sauer, and Pediatrics
- Subjects
Cord ,Physiology ,Breast milk ,Dioxins ,Nervous System ,Toxicology ,Pregnancy ,Humans ,Medicine ,Prenatal exposure ,Milk, Human ,business.industry ,food and beverages ,Obstetrics and Gynecology ,Environmental Exposure ,Environmental exposure ,Fetal Blood ,Polychlorinated Biphenyls ,Neurological effects ,Pcb exposure ,El Niño ,Child, Preschool ,Prenatal Exposure Delayed Effects ,Pediatrics, Perinatology and Child Health ,Toxicity ,Regression Analysis ,Female ,business - Abstract
Adverse neurological effects of exposure to PCBs have been found up to 18 months of age. Now we report on the effect of pre- and postnatal exposure to PCBs and dioxins on the neurological condition at 42 months of age. For this purpose, PCB levels were determined in cord and maternal plasma, and used as a measure of prenatal exposure. Breast milk was analyzed for PCBs and dioxins. In addition, PCBs were determined in plasma sampled from the child at 42 months of age. We evaluated the neurological condition of 394 children using the Touwen/Hempel method. After adjustment for covariates, neither prenatal PCB exposure nor postnatal exposure to PCBs and dioxins was found to be related to the neurological condition at 42 months of age.
- Published
- 1998