10 results on '"Samai, Mohamed"'
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2. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone
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Mooney, T, Conteh, L, Bangura, MS, Bangura, MA, Jalloh, H, Kamara, I, Kamara, M, Koroma, S, Sesay, M, Sesay, MT, Deen, AT, Kamara, A, Kamara, EL, Kamara, SLM, Koroma, AH, Mansaray, IS, Massaquoi, MJ, Nabie, A, Kowuor, D, Njie, Y, Odeny, L, Sheku, M, Jalloh, AB, Sow, A, Swaray, E, Mansaray, F, Sessie, T, Sunders, J-HC, Turay, SI-S, Weekes, J, Pessima, M, Wurie, A, Conteh, M, Jalloh, MI, Kamara, PBD, Kanneh, DP, Kanneh, M, Komeh, I, Koroma, M, Kuyateh, M, Mansaray, FF, Leigh, B, Watson-Jones, D, Samai, M, Deen, GF, Sesay, T, Piot, P, Greenwood, B, Lees, S, Larson, H, Afolabi, M, Ishola, D, Baiden, F, Faye, F, Tindanbil, D, Kamara, MM, Swaray, IB, Bangura, A, Kamara, AB, Morovia, FE, Kallon, JA, Murray, M, Sesay, F, Suma, F, Sesay, IG, Choi, EM, Manno, D, Foster, J, Rwezaula, R, Akhigbe, I, Adetola, H, Kamara, B, Lowe, B, Lawal, B, Kohn, B, Tuda, GO, Koroma, F, Bangura, G, Kroma, MT, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Fangawa, J, Foday, S, Jabbie, I, Mansaray, HA, Sesay, K, Jakema, HB, Sheku, MF, Jalloh, KFN, Kabba, M, Kanjie, F, Kanu, AP, Kassa-Koroma, G, Jusu, M, Koroma, B, Borboh, P, Kallon, A, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Kalokoh, J, Bangura, MI, Connor, N, Saidu, S, Turay, AS, Lahai, A, Johnson, CL, Kogba, DB, Vincent, W, Bangura, M, Tengbeh, A, Bangura, K, Kabia, R, Nyakoi, AM, Lee, S, Nyaberi, D, Ndingi, S, Nyallay, L, Bangura, AR, Idriss, B, Sillah, M, Mackay, W, Murray, T, Edem-Hotah, J, Fatorma, T, Bangura, S, Bonnie, E, Sannoh, M, Malcolm, S, Brown, J, Snowden, E, Howard, K, Ojugo, A, Massin-Shepherd, C, BEAVOGUI, AH, KEITA, CM, CAMARA, OK, GUILAVOGUI, JPY, BAH, H, SAMOURA, MA, MUAMBA, D, SEMAKUBA, B, CAMARA, AK, KABA, AS, BERERD-CAMARA, M, YARADOUNO, M, DECHENAUD, M, CAMARA, MT, TAMBALOU, J, HABA, M, DIALLO, SD, THEA, A, DOUMBOUYA, N, FOFANA, ML, BEAVOGUI, M, CAMARA, AA, BEAVOGUI, JT, DIOUF, W, AUGIER, A, BARTE DE SAINTE FARE, E, SIVAHERA MUYISA, B, SANI, S, VATRINET, R, HAMZE, B, LACARRA, B, D’ORTENZIO, E, ALE, B, BETARD, C, RICHERT, L, OULAI, D, KANTE, M, SOUTTHIPHONG, A-A, SCHWIMMER, C, THIÉBAUT, R, OTTAVI, A, COUFFIN-CADIERGUES, S, ESPEROU, H, Chai, SP, Buth, W, Offergeld, K, Menten, A, Hammoud, N, De Ridder, S, Sellecchia, R, in ’t Veld, R, Fogap, N, Anumendem, D, Stapleton, H, Reijns, T, Haydon, J, Roza, L, Sawyer, B, Hoda, S, Yee, J, De Cnodder, T, Hubin, E, Telen, L, Desai, J, Bennet, M, Pawlowski, M, van Gils, N, Boeykens, N, Kwasniak, A, Ligthart, M, Van Roey, G, Fernandez, E, Gaddah, A, van Dijck, W, Jingshuang, S, Randrasana, S, Artis, C, Akinbinu, A, Poretti, A, Van Ballaert, S, Harris, M, Van Looveren, M, Brandt, P, Robinson, C, Bockstal, V, McLean, C, Versteege, I, Ferrault, C, Kaminski, A, Vergauwen, H, Kerama, CI, Forcheh, CA, DiMondi, CV, Stewart, L, Meurer, J, Beounitis, A, Peeters, J, Su, C, Keshinro, B, Delport, C, Sharkie, E, Zhang, J, Du, C, Hu, K, Strydom, A, Bezem-Aviv, I, Wachnicka, A, Kumar, P, Cheng, S, Kang, K, Choi, Edward Man-Lik, Lacarra, Boris, Afolabi, Muhammed O, Ale, Boni Maxime, Baiden, Frank, Bétard, Christine, Foster, Julie, Hamzé, Benjamin, Schwimmer, Christine, Manno, Daniela, D’Ortenzio, Eric, Ishola, David, Keita, Cheick Mohamed, Keshinro, Babajide, Njie, Yusupha, van Dijck, Wim, Gaddah, Auguste, Anumendem, Dickson, Lowe, Brett, Vatrinet, Renaud, Lawal, Bolarinde Joseph, Otieno, Godfrey T, Samai, Mohamed, Deen, Gibrilla Fadlu, Swaray, Ibrahim Bob, Kamara, Abu Bakarr, Kamara, Michael Morlai, Diagne, Mame Aminata, Kowuor, Dickens, McLean, Chelsea, Leigh, Bailah, Beavogui, Abdoul Habib, Leyssen, Maarten, Luhn, Kerstin, Robinson, Cynthia, Douoguih, Macaya, Greenwood, Brian, Thiébaut, Rodolphe, and Watson-Jones, Deborah
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- 2023
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3. A new simplified approach for predicting the bearing capacity of rectangular concrete four-pile caps
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Boulifa, Ridha, Goudjil, Kamel, and Samai, Mohamed Laid
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- 2023
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4. Prevalence of immunoglobulin G and M to SARS-CoV-2 and other human coronaviruses in The Democratic Republic of Congo, Sierra Leone, and Uganda: A longitudinal study
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Lawal, Bolarinde J., Gallagher, Katherine E., Kitonsa, Jonathan, Tindanbil, Daniel, Kasonia, Kambale, Drammeh, Abdoulie, Lowe, Brett, Mukadi-Bamuleka, Daniel, Patterson, Catriona, Greenwood, Brian, Samai, Mohamed, Leigh, Bailah, Tetteh, Kevin K.A., Ruzagira, Eugene, Watson-Jones, Deborah, and Kavunga-Membo, Hugo
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- 2023
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5. Safety and immunogenicity of an Ad26.ZEBOV booster dose in children previously vaccinated with the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen: an open-label, non-randomised, phase 2 trial
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Manno, Daniela, Bangura, Agnes, Baiden, Frank, Kamara, Abu Bakarr, Ayieko, Philip, Kallon, Joseph, Foster, Julie, Conteh, Musa, Connor, Nicholas Edward, Koroma, Bockarie, Njie, Yusupha, Borboh, Paul, Keshinro, Babajide, Lawal, Bolarinde Joseph, Kroma, Mattu Tehtor, Otieno, Godfrey Tuda, Deen, Abdul Tejan, Choi, Edward Man-Lik, Balami, Ahmed Dahiru, Gaddah, Auguste, McLean, Chelsea, Luhn, Kerstin, Adetola, Hammed Hassan, Deen, Gibrilla Fadlu, Samai, Mohamed, Lowe, Brett, Robinson, Cynthia, Leigh, Bailah, Greenwood, Brian, and Watson-Jones, Deborah
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- 2023
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6. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in children in Sierra Leone: a randomised, double-blind, controlled trial
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Kargbo, M, Bockarie, E, James, N L, Kabbah, A, Kamara, A, Koroma, K H, Langley, S O, William, N, Kessebeh, R, Mooney, T, Conteh, L, Smout, E, Allieu, K, Bangura, K, Bangura, M S, Bangura, M A, Jalloh, H, Jalloh, A B, Kamara, I, Kamara, M, Konteh, A, Koroma, S, Marrah, C, Sesay, M, Sesay, M T, Deen, A T, Jalloh, A, Kaimbay, R M, Kain, D, Kamara, E L, Kamara, M P, Kamara, O J, Kamara, S L M, Kanneh, M, Koroma, A H, Lahai, D, Mansaray, I S, Marah, W S, Massaquoi, M J, Nabie, A, Saidu, N S, Samai, I, Tengheh, J N, Turay, A S, Fornah, A, Sesay, F, Sow, A, Swaray, E, Mansaray, F, Ade-Cole, T, Bangura, L M, Conteh, M L, Koroma, A M, Koroma, M, Sam, A, Scott, T, Sessie, T, Sunders, J-H C, Turay, S I-S, Weekes, J, Sheku, M, Gibson, L, Kowuor, D, Ahamed, I, Allieu, W, Kabba, D U, Kamara, F J, Kebbie, M S, Pessima, M, Wurie, A, Bah, F, Bangura, A I, Bangura, R A S, Blango, L, Boima, S, Conteh, M, Conteh, Y, Daramy, M L, Fofanah, O, George, E, Hanson, T F, Jalloh, M I, Kalawa, M, Kamara, A M, Kamara, F E, Kamara, G M, Kamara, H M, Kamara, P B D, Kamara, R T, Kamara, R, Kanneh, D P, Komeh, I, Kuyateh, M, Mansaray, F F, Mansaray, M M, Sillah, A B, Tarawally, M A, Turya, O S, Yawmah, J B, Leigh, B, Watson-Jones, D, Greenwood, B, Samai, M H, Deen, G F, Marke, D, Sesay, T, Piot, P, Smith, P, Edmunds, J, Lees, S, Larson, H, Weiss, H, Wilson, P, Phillips, R, Maxwell, C, Ishola, D, Afolabi, M, Baiden, F, Akoo, P, Owusu-Kyei, K, Tindanbil, D, Bower, H, Stuart, J, Bah, O M, Rogers, B T, Serry-Bangura, A, Swaray, I B, Bangura, A, David, I J, Davies, D G M, Kallon, J A, Kamara, A B, Kamara, I F, Kamara, M M, Morovia, F E, Suma, F B, Thompson, F, Murray, M, Kakay, O, Suma, F, Sesay, I, Foster, J, Manno, D, Gallagher, K, Cox, S, Howard, N, Cesay, M, Torrani, P, Sharma, S, Snowden, E, Banks, T, Harber, T, Brown, J, Howard, K, Melton, N, Malcolm, S, Welsh, S, Eggo, R, Jendrossek, M, Pearson, C, Offergeld, K, Ferrault, C, Van Alst, M, Mahajan, N, Van Looveren, M, Van Ballaert, S, De Cnodder, T, Grobler, N, Roza, L, Liberi, T, Armishaw, L, Verkleij, C, Henrick, T, Banaszkiewicz, A, Lowe, B, Awuondo, K, Hafezi, H, Hancox, E, Kohn, B, Tuda, G O, Bangura, G, Kroma, M T, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Ajala, T W, Fangawa, J, Foday Jr, S, Koroma, I S F, Mansaray, B, Mansaray, H A, Sesay, K, Charles, M K, Heroe, P C, Lamin Karbo, M, Yansaneh, I S, Gogo Egoeh, S, Trye, A, Amponsah, M, Donelson, L, Sylvester, T, Owira, V, Onyuka, G, Nambuchi, L, Oburu, A, Apollo, D, Vandi, L, Alghali, N D, Bah, A, Bangura, I J, Cole, A C, Fofanah, S, Jalloh, H U, Jalloh, K F N, Jalloh, N, Kabba, H U, Kabba, J N, Kabba, M, Kamara, J S, Kanjie, F, Kanu, A P, Kargbo, I, Kassa-Koroma, G, Koroma, S B, Sankoh, A, Sankoh, T, Sesay, O D, Wilhem, H, Williams, C T, Bangura, I, Ben-Rogers, Y, Jamboria, F J, Kamara, N, Kanawah, I, Kargbo, A T, Swaray, I, Amara, L, Bundu, I, Jakema, H B, Kamara, K, Sheku, M F, Adeleye, Q, Akhigbe, I, Bakalemwa, R, Chami, N P, Altmann, L, Kamara, B, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Moinina, E, Kalokoh, J, Bosompem, S, Hilton, T, Jusu, M O, Borboh, P, Brima, A S, Caulker, A F Y, Kallon, A, Koroma, B, Macauley, R C, Saquee, T M D, Williams, H I, Bangura, A R, Fornah, J, Idriss, B, Sillah, M, Mackay, W, Aleghen, B, Murray, T, Edem-Hotah, J, Fatorma, T, Amara, F, Bangura, S, Bonnie, E, Sannoh, M, Donaldson, A, Ndingi, S, Nyaberi, D, Pereira, M, Rothwell, A, Vy, V, Nyallay, L, Fombah, A, Saidu, S, Dambo, T P, Fakaba, P J, Fatorma, M M E, Freeman, R H, Johnson, C L, Kogba, D B, Lahai, A, Vincent, W, Yambasu, N, Bangura, M, Tengbeh, A, Kabia, R, Nyakoi, A M, Callaghan, M, Enria, L, Lee, S, Afolabi, Muhammed O, Ishola, David, Manno, Daniela, Keshinro, Babajide, Bockstal, Viki, Rogers, Baimba, Owusu-Kyei, Kwabena, Serry-Bangura, Alimamy, Swaray, Ibrahim, Lowe, Brett, Kowuor, Dickens, Baiden, Frank, Mooney, Thomas, Smout, Elizabeth, Köhn, Brian, Otieno, Godfrey T, Jusu, Morrison, Foster, Julie, Samai, Mohamed, Deen, Gibrilla Fadlu, Larson, Heidi, Lees, Shelley, Goldstein, Neil, Gallagher, Katherine E, Gaddah, Auguste, Heerwegh, Dirk, Callendret, Benoit, Luhn, Kerstin, Robinson, Cynthia, Greenwood, Brian, Leyssen, Maarten, Douoguih, Macaya, Leigh, Bailah, and Watson-Jones, Deborah
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- 2022
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7. Safety and long-term immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in adults in Sierra Leone: a combined open-label, non-randomised stage 1, and a randomised, double-blind, controlled stage 2 trial
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Kargbo, M, Bockarie, E, James, N L, Kabbah, A, Kamara, A, Koroma, K H, Langley, S O, William, N, Kessebeh, R, Mooney, T, Conteh, L, Smout, E, Allieu, K, Bangura, K, Bangura, M S, Bangura, M A, Jalloh, H, Jalloh, A B, Kamara, I, Kamara, M, Konteh, A, Koroma, S, Marrah, C, Sesay, M, Sesay, M T, Deen, A T, Jalloh, A, Kaimbay, R M, Kain, D, Kamara, E L, Kamara, M P, Kamara, O J, Kamara, S L M, Kanneh, M, Koroma, A H, Lahai, D, Mansaray, I S, Marah, W S, Massaquoi, M J, Nabie, A, Saidu, N S, Samai, I, Tengheh, J N, Turay, A S, Fornah, A, Sesay, F, Sow, A, Swaray, E, Mansaray, F, Ade-Cole, T, Bangura, L M, Conteh, M L, Koroma, A M, Koroma, M, Sam, A, Scott, T, Sessie, T, Sunders, J-H C, Turay, S I-S, Weekes, J, Sheku, M, Gibson, L, Kowuor, D, Ahamed, I, Allieu, W, Kabba, D U, Kamara, F J, Kebbie, M S, Pessima, M, Wurie, A, Bah, F, Bangura, A I, Bangura, R A S, Blango, L, Boima, S, Conteh, M, Conteh, Y, Daramy, M L, Fofanah, O, George, E, Hanson, T F, Jalloh, M I, Kalawa, M, Kamara, A M, Kamara, F E, Kamara, G M, Kamara, H M, Kamara, P B D, Kamara, R T, Kamara, R, Kanneh, D P, Komeh, I, Kuyateh, M, Mansaray, F F, Mansaray, M M, Sillah, A B, Tarawally, M A, Turya, O S, Yawmah, J B, Leigh, B, Watson-Jones, D, Greenwood, B, Samai, M H, Deen, G F, Marke, D, Piot, P, Smith, P, Edmunds, J, Lees, S, Larson, H, Weiss, H, Wilson, P, Maxwell, C, Ishola, D, Afolabi, M, Baiden, F, Akoo, P, Owusu-Kyei, K, Tindanbil, D, Bower, H, Stuart, J, Bah, O M, Rogers, B T, Serry-Bangura, A, Swaray, I B, Bangura, A, David, I J, Davies, D G M, Kallon, J A, Kamara, A B, Kamara, I F, Kamara, M M, Morovia, F E, Suma, F B, Thompson, F, Murray, M, Sesay, I, Kakay, O, Suma, F, Foster, J, Philips, R, Manno, D, Gallager, K, Cox, S, Howard, N, Cesay, M, Torrani, P, Sharma, S, Snowden, E, Banks, T, Harber, T, Brown, J, Howard, K, Melton, N, Malcolm, S, Welsh, S, Eggo, R, Jendrossek, M, Pearson, C, Van Hoof, J, Douoguih, M, Offergelt, K, Robinson, C, Keshinro, B, Van Alst, M, Mahajan, N, Bockstal, V, Goldstein, N, Gaddah, A, Heerwegh, D, Luhn, K, Leyssen, M, Lowe, B, Awuondo, K, Hafezi, H, Hancox, E, Kohn, B, Tuda, G O, Koroma, F, Bangura, G, Kroma, M T, Fofanah, L, Pessima, A, Rogers, M, Sheriff, O, Ajala, T W, Fangawa, J, Foday Jr, S, Jabbie, I, Mansaray, B, Mansaray, H A, Sesay, K, Charles, M K, Heroe, P C, Karbo, M L, Yansaneh, IS, Egoeh, S G, Trye, A, Amponsah, M, Alghali, N D, Bah, A, Bangura, IJ, Cole, A C, Fofanah, K, Fofanah, S, Jalloh, H U, Jalloh, K F N, Jalloh, N, Kabba, H U, Kabba, J N, Kabba, M, Kamara, J S, Kanjie, F, Kanu, A P, Kargbo, I, Kassa-Koroma, G, Koroma, S B, Sankoh, A, Sankoh, T, Sesay, O D, Wilhem, H, Williams, C T, Bangura, I, Ben-Rogers, Y, Jamboria, F J, Kamara, N, Kanawah, I, Kargbo, A T, Swaray, I, Amara, L, Bundu, I, Jakema, H B, Kamara, K, Sheku, M F, Adeleye, Q, Akhigbe, I, Bakalemwa, R, Chami, N P, Sylvester, T, Altmann, L, Kamara, B, van Roey, K, Conteh, P, Samura, M, Gandie, V, Marrah, M, Moinina, E, Kalokoh, J, Bangura, M I, Bosompem, S, Hilton, T, Jusu, M O, Borboh, P, Brima, A S, Caulker, A F Y, Kallon, A, Koroma, B, Macauley, RC, Saquee, T M D, Williams, H I, Bangura, A R, Fornah, J, Idriss, B, Sillah, M, Mackay, W, Aleghen, B, Murray, T, Edem-Hotah, J, Fatorma, T, Amara, F, Bangura, S, Bonnie, E, Sannoh, M, Donaldson, A, Ndingi, S, Nyaberi, D, Pereira, M, Rothwell, A, Vy, V, Nyallay, L, Fombah, A, Saidu, S, Connor, N, Dambo, T P, Fakaba, P J, Fatorma, M M E, Johnson, C L, Kogba, D B, Lahai, A, Vincent, W, Yambasu, N, Bangura, M, Tengbeh, A, Kabia, R, Nyakoi, AM, Callaghan, M, Enria, L, Lee, S, Ishola, David, Manno, Daniela, Afolabi, Muhammed O, Keshinro, Babajide, Bockstal, Viki, Rogers, Baimba, Owusu-Kyei, Kwabena, Serry-Bangura, Alimamy, Swaray, Ibrahim, Lowe, Brett, Kowuor, Dickens, Baiden, Frank, Mooney, Thomas, Smout, Elizabeth, Köhn, Brian, Otieno, Godfrey T, Jusu, Morrison, Foster, Julie, Samai, Mohamed, Deen, Gibrilla Fadlu, Larson, Heidi, Lees, Shelley, Goldstein, Neil, Gallagher, Katherine E, Gaddah, Auguste, Heerwegh, Dirk, Callendret, Benoit, Luhn, Kerstin, Robinson, Cynthia, Leyssen, Maarten, Greenwood, Brian, Douoguih, Macaya, Leigh, Bailah, and Watson-Jones, Deborah
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- 2022
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8. Burns in Sierra Leone: A population-based assessment
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Wong, Evan G., Groen, Reinou S., Kamara, Thaim B., Stewart, Kerry-Ann, Cassidy, Laura D., Samai, Mohamed, Kushner, Adam L., and Wren, Sherry M.
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- 2014
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9. Rates of caesarean section and total volume of surgery in Sierra Leone: a retrospective survey
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Bolkan, Håkon A, von Schreeb, Johan, Samai, Mohamed M, Bash-Taqi, Donald A, Kamara, Thaim B, Salvesen, Øyvind, Ystgaard, Brynjulf, and Wibe, Arne
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- 2015
- Full Text
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10. Safety and immunogenicity of the two-dose heterologous Ad26.ZEBOV and MVA-BN-Filo Ebola vaccine regimen in infants: a phase 2, randomised, double-blind, active-controlled trial in Guinea and Sierra Leone.
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Choi EM, Lacarra B, Afolabi MO, Ale BM, Baiden F, Bétard C, Foster J, Hamzé B, Schwimmer C, Manno D, D'Ortenzio E, Ishola D, Keita CM, Keshinro B, Njie Y, van Dijck W, Gaddah A, Anumendem D, Lowe B, Vatrinet R, Lawal BJ, Otieno GT, Samai M, Deen GF, Swaray IB, Kamara AB, Kamara MM, Diagne MA, Kowuor D, McLean C, Leigh B, Beavogui AH, Leyssen M, Luhn K, Robinson C, Douoguih M, Greenwood B, Thiébaut R, and Watson-Jones D
- Subjects
- Animals, Humans, Infant, Sierra Leone, Guinea, Antibodies, Viral, Double-Blind Method, Glycoproteins, Fever, Ebola Vaccines adverse effects, Hemorrhagic Fever, Ebola prevention & control, Ebolavirus
- Abstract
Background: This study assessed the safety and immunogenicity of the Ad26.ZEBOV and MVA-BN-Filo Ebola virus (EBOV) vaccine regimen in infants aged 4-11 months in Guinea and Sierra Leone., Methods: In this phase 2, randomised, double-blind, active-controlled trial, we randomly assigned healthy infants (1:1 in a sentinel cohort, 5:2 for the remaining infants via an interactive web response system) to receive Ad26.ZEBOV followed by MVA-BN-Filo (Ebola vaccine group) or two doses of meningococcal quadrivalent conjugate vaccine (control group) administered 56 days apart. Infants were recruited at two sites in west Africa: Conakry, Guinea, and Kambia, Sierra Leone. All infants received the meningococcal vaccine 8 months after being randomly assigned. The primary objective was safety. The secondary objective was immunogenicity, measured as EBOV glycoprotein-binding antibody concentration 21 days post-dose 2, using the Filovirus Animal Non-Clinical Group ELISA. This study is registered with ClinicalTrials.gov (NCT03929757) and the Pan African Clinical Trials Registry (PACTR201905827924069)., Findings: From Aug 20 to Nov 29, 2019, 142 infants were screened and 108 were randomly assigned (Ebola vaccine n=75; control n=33). The most common solicited local adverse event was injection-site pain (Ebola vaccine 15 [20%] of 75; control four [12%] of 33). The most common solicited systemic adverse events with the Ebola vaccine were irritability (26 [35%] of 75), decreased appetite (18 [24%] of 75), pyrexia (16 [21%] of 75), and decreased activity (15 [20%] of 75). In the control group, ten (30%) of 33 had irritability, seven (21%) of 33 had decreased appetite, three (9%) of 33 had pyrexia, and five (15%) of 33 had decreased activity. The frequency of unsolicited adverse events was 83% (62 of 75 infants) in the Ebola vaccine group and 85% (28 of 33 infants) in the control group. No serious adverse events were vaccine-related. In the Ebola vaccine group, EBOV glycoprotein-binding antibody geometric mean concentrations (GMCs) at 21 days post-dose 2 were 27 700 ELISA units (EU)/mL (95% CI 20 477-37 470) in infants aged 4-8 months and 20 481 EU/mL (15 325-27 372) in infants aged 9-11 months. The responder rate was 100% (74 of 74 responded). In the control group, GMCs for both age groups were less than the lower limit of quantification and the responder rate was 3% (one of 33 responded)., Interpretation: Ad26.ZEBOV and MVA-BN-Filo was well tolerated and induced strong humoral responses in infants younger than 1 year. There were no safety concerns related to vaccination., Funding: Janssen Vaccines & Prevention and Innovative Medicines Initiative 2 Joint Undertaking., Translation: For the French translation of the abstract see Supplementary Materials section., Competing Interests: Declaration of interests Janssen Vaccines & Prevention was the vaccine manufacturer and donated the vaccine for this study. BK, WvD, AG, DA, CM, ML, KL, CR, and MD were full-time employees of Janssen Pharmaceuticals at the time of the study and hold stock or stock options in Janssen Pharmaceuticals. All other authors declare funding from the Innovative Medicines Initiative 2 Joint Undertaking., (Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
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