1. Corticotropin (ACTH)-reactive immunoglobulins in adolescents in relation to antisocial behavior and stress-induced cortisol response. The TRAILS study
- Author
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Romain Legrand, Pieter J. Hoekstra, Floor V. A. van Oort, Sergueï O. Fetissov, Johanna M. Schaefer, Frank C. Verhulst, Sophie Claeyssens, Child and Adolescent Psychiatry / Psychology, and Public Health
- Subjects
Male ,SALIVARY CORTISOL ,Hydrocortisone ,Population sample ,Endocrinology, Diabetes and Metabolism ,Pituitary-Adrenal System ,CHILDREN ,Social Environment ,Endocrinology ,Antisocial behavior ,Child ,EXTERNALIZING BEHAVIOR ,SOCIAL STRESS ,POPULATION ,Salivary cortisol ,Glutathione Transferase ,Sex Characteristics ,Antisocial Personality Disorder ,Adolescence ,MSH REACTIVE AUTOANTIBODIES ,Psychiatry and Mental health ,Conduct disorder ,SELF-REPORTED DELINQUENCY ,ACTH immunoglobulins ,Female ,Antibody ,hormones, hormone substitutes, and hormone antagonists ,ACTH autoantibodies ,Hypothalamo-Hypophyseal System ,endocrine system ,medicine.medical_specialty ,Adolescent ,Immunoglobulins ,Biology ,Adrenocorticotropic Hormone ,Internal medicine ,medicine ,Humans ,Biological Psychiatry ,Social stress ,Endocrine and Autonomic Systems ,HPA axis ,Stress response ,Stress induced ,Binding properties ,AGGRESSIVE-BEHAVIOR ,medicine.disease ,Kinetics ,CONDUCT DISORDER ,Immunoglobulin G ,Exercise Test ,biology.protein ,PITUITARY-ADRENAL AXIS ,Stress, Psychological - Abstract
Elevated levels of corticotropin (ACTH)-reactive immunoglobulins (ACTH IgG) were found in mates with conduct disorder, suggesting their involvement in the biology of antisocial behavior. We first aimed to confirm these findings in a large general population sample of adolescents. Secondly, we studied the association between ACTH IgG levels and hypothalamic-pituitary-adrenal (HPA) axis response to stress.Free and total ACTH IgG levels were measured in sera of 1230 adolescents (15-18 years). HPA axis activity was determined by measuring salivary cortisol before, during, and after a social stress test. Antisocial behavior was assessed using the Antisocial Behavior Questionnaire. ACTH peptide and IgG affinity kinetics for ACTH were assayed in a subsample of 90 adolescents selected for high or low ACTH IgG levels.In boys, higher total ACTH IgG levels were associated with higher antisocial behavior scores (beta = 1.05, p = 0.04), especially at high levels of free ACTH IgG. In girls, antisocial behavior was associated with low free ACTH IgG levels (beta = -0.20, p = 0.04). Stress-induced cortisol release was associated with free ACTH IgG in boys (beta(area under the curve) = -0.67, p These data show that ACTH IgG levels are related to antisocial behavior and HPA axis response to stress in adolescents. The mechanisms behind these associations, including different ACTH binding properties of IgG in subjects with antisocial behavior, deserve further attention. (C) 2013 Elsevier Ltd. All rights reserved.
- Published
- 2013