1. Ancestral origin, antigenic resemblance and epidemiological insights of novel coronavirus (SARS-CoV-2): Global burden and Bangladesh perspective.
- Author
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Uddin MB, Hasan M, Harun-Al-Rashid A, Ahsan MI, Imran MAS, and Ahmed SSU
- Subjects
- Alphacoronavirus classification, Alphacoronavirus genetics, Alphacoronavirus metabolism, Amino Acid Sequence, Animals, Antigens, Viral chemistry, Antigens, Viral metabolism, Bangladesh epidemiology, Base Sequence, Betacoronavirus classification, Betacoronavirus metabolism, Binding Sites, COVID-19, Chiroptera virology, Computational Biology, Coronavirus 229E, Human classification, Coronavirus 229E, Human genetics, Coronavirus 229E, Human metabolism, Coronavirus Infections virology, Coronavirus NL63, Human classification, Coronavirus NL63, Human genetics, Coronavirus NL63, Human metabolism, Coronavirus OC43, Human classification, Coronavirus OC43, Human genetics, Coronavirus OC43, Human metabolism, Humans, Middle East Respiratory Syndrome Coronavirus classification, Middle East Respiratory Syndrome Coronavirus genetics, Middle East Respiratory Syndrome Coronavirus metabolism, Models, Molecular, Mutation, Nucleoproteins chemistry, Nucleoproteins genetics, Nucleoproteins metabolism, Phylogeny, Pneumonia, Viral virology, Protein Binding, Protein Interaction Domains and Motifs, Severe acute respiratory syndrome-related coronavirus classification, Severe acute respiratory syndrome-related coronavirus metabolism, SARS-CoV-2, Sequence Alignment, Spike Glycoprotein, Coronavirus genetics, Spike Glycoprotein, Coronavirus metabolism, Viral Envelope Proteins chemistry, Viral Envelope Proteins genetics, Viral Envelope Proteins metabolism, Antigens, Viral genetics, Betacoronavirus genetics, Coronavirus Infections epidemiology, Genome, Viral, Pandemics, Pneumonia, Viral epidemiology, Severe acute respiratory syndrome-related coronavirus genetics, Spike Glycoprotein, Coronavirus chemistry
- Abstract
SARS-CoV-2, a new coronavirus strain responsible for COVID-19, has emerged in Wuhan City, China, and continuing its global pandemic nature. The availability of the complete gene sequences of the virus helps to know about the origin and molecular characteristics of this virus. In the present study, we performed bioinformatic analysis of the available gene sequence data of SARS-CoV-2 for the understanding of evolution and molecular characteristics and immunogenic resemblance of the circulating viruses. Phylogenetic analysis was performed for four types of representative viral proteins (spike, membrane, envelope and nucleoprotein) of SARS-CoV-2, HCoV-229E, HCoV-OC43, SARS-CoV, HCoV-NL63, HKU1, MERS-CoV, HKU4, HKU5 and BufCoV-HKU26. The findings demonstrated that SARS-CoV-2 exhibited convergent evolutionary relation with previously reported SARS-CoV. It was also depicted that SARS-CoV-2 proteins were highly similar and identical to SARS-CoV proteins, though proteins from other coronaviruses showed a lower level of resemblance. The cross-checked conservancy analysis of SARS-CoV-2 antigenic epitopes showed significant conservancy with antigenic epitopes derived from SARS-CoV. Descriptive epidemiological analysis on several epidemiological indices was performed on available epidemiological outbreak information from several open databases on COVID-19 (SARS-CoV-2). Satellite-derived imaging data have been employed to understand the role of temperature in the environmental persistence of the virus. Findings of the descriptive analysis were used to describe the global impact of newly emerged SARS-CoV-2, and the risk of an epidemic in Bangladesh., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020 Elsevier B.V. All rights reserved.)
- Published
- 2020
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