1. Development of machine learning models to predict papillary carcinoma in thyroid nodules: The role of immunological, radiologic, cytologic and radiomic features.
- Author
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Canali L, Gaino F, Costantino A, Guizzardi M, Carnicelli G, Gullà F, Russo E, Spriano G, Giannitto C, and Mercante G
- Subjects
- Humans, Female, Male, Middle Aged, Retrospective Studies, Adult, Aged, Area Under Curve, Carcinoma, Papillary diagnostic imaging, Carcinoma, Papillary pathology, Radiomics, Machine Learning, Thyroid Nodule diagnostic imaging, Thyroid Nodule pathology, Thyroid Cancer, Papillary diagnostic imaging, Thyroid Cancer, Papillary pathology, Thyroid Cancer, Papillary immunology, Thyroid Neoplasms diagnostic imaging, Thyroid Neoplasms pathology, Thyroid Neoplasms immunology, Ultrasonography
- Abstract
Objective: Approximately 30 % of thyroid nodules yield an indeterminate diagnosis through conventional diagnostic strategies. The aim of this study was to develop machine learning (ML) models capable of identifying papillary thyroid carcinomas using preoperative variables., Methods: Patients with thyroid nodules undergoing thyroid surgery were enrolled in a retrospective monocentric study. Six 2-class supervised ML models were developed to predict papillary thyroid carcinoma, by sequentially incorporating clinical-immunological, ultrasonographic, cytological, and radiomic variables., Results: Out of 186 patients, 92 nodules (49.5 %) were papillary thyroid carcinomas in the histological report. The Area Under the Curve (AUC) ranged from 0.41 to 0.61 using only clinical-immunological variables. All ML models exhibited an increased performance when ultrasound variables were included (AUC: 0.95-0.97). The addition of cytological (AUC: 0.86-0.97) and radiomic (AUC: 0.88-0.97) variables did not further improve ML models' performance., Conclusion: ML algorithms demonstrated low accuracy when trained with clinical-immunological data. However, the inclusion of radiological data significantly improved the models' performance, while cytopathological and radiomics data did not further improve the accuracy., Level of Evidence: Level 4., Competing Interests: Declaration of competing interest All the authors of this study have no conflict of interest to declare., (Copyright © 2024. Published by Elsevier B.V.) more...
- Published
- 2024
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