1. Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
- Author
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Yang MH, Yoon KD, Chin YW, Park JH, and Kim J
- Subjects
- Cyclooxygenase 2 Inhibitors metabolism, Dibenzoxepins chemistry, Dibenzoxepins isolation & purification, Dibenzoxepins pharmacology, Free Radical Scavengers isolation & purification, Free Radical Scavengers pharmacology, Phenols isolation & purification, Phenols pharmacology, Plant Extracts chemistry, Stilbenes chemistry, Stilbenes isolation & purification, Stilbenes pharmacology, Cyclooxygenase 2 Inhibitors chemistry, Dioscorea chemistry, Free Radical Scavengers chemistry, Phenols chemistry
- Abstract
Phytochemical studies of the chloroform soluble fraction of Dioscorea opposita resulted in the isolation of four new compounds, 3,5-dihydroxy-4-methoxybibenzyl (1), 3,3',5-trihydroxy-2'-methoxybibenzyl (2), 10,11-dihydro-dibenz[b,f]oxepin-2,4-diol (3), and 10,11-dihydro-4-methoxy-dibenz[b,f]oxepin-2-ol (4), together with an additional fifteen known compounds. The structures of 1-4 were elucidated by spectroscopic methods including 2D NMR. All of the nineteen isolated compounds were tested in the DPPH, superoxide anion radical scavenging assays and cyclooxygenases (COXs) inhibition assay. Of those, compounds 7, 9, 11, 12, 13, 15 and 18 exhibited radical scavenging activities and compounds 2, 3, 8, 13, 15 and 16 showed selective inhibitory activities against COX-2.
- Published
- 2009
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