1. Cerebellar degeneration and progressive ataxia associated with HIV-virus infection.
- Author
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Pedroso JL, Vale TC, Gama MTD, Ribas G, Kristochik JCG, Germiniani FMB, Fink MCDDS, Oliveira ACP, Teive HAG, and Barsottini OG
- Subjects
- Adult, Atrophy pathology, Cerebellar Ataxia diagnostic imaging, Cerebellar Ataxia physiopathology, Cerebellum diagnostic imaging, Cohort Studies, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Spinocerebellar Degenerations diagnostic imaging, Spinocerebellar Degenerations physiopathology, Cerebellar Ataxia etiology, Cerebellum pathology, HIV Infections complications, Spinocerebellar Degenerations etiology
- Abstract
Introduction: The spectrum of neurologic disorders associated with HIV infection is very broad, resulting from direct virus invasion, opportunistic infections, malignancies and toxic effects of drugs., Methods: Among a large cohort of ataxia patients (N = 1050) evaluated between 2008 and 2017, we detected four patients with HIV-infection who developed a pure progressive cerebellar ataxia syndrome combined with cerebellar atrophy., Results: Adverse drug effects, opportunistic infections and malignancies as well as immune-reconstitution syndrome were ruled out based on history and laboratory data. The exact pathophysiological mechanisms of ataxia in HIV patients is not very clear, but seems to be immune-mediated or a direct neurotoxic virus effect leading to apoptosis of Purkinje and granular cells., Conclusion: HIV infection should be investigated in adult patients with undetermined sporadic progressive pure ataxia with cerebellar atrophy., (Copyright © 2018 Elsevier Ltd. All rights reserved.)
- Published
- 2018
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