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Your search keyword '"Guelman, Laura Ruth"' showing total 2 results
Start Over Author "Guelman, Laura Ruth" Publisher elsevier science
2 results on '"Guelman, Laura Ruth"'

1. Effects of loud noise on hippocampal and cerebellar-related behaviors.: Role of oxidative state

Author

Urán, Soledad Lucía, Cáceres, Lucila Guadalupe, and Guelman, Laura Ruth

Subjects
Behavior, Medicina Básica, CIENCIAS MÉDICAS Y DE LA SALUD, Cerebellum, Neurociencias, Hippocampus, Loud Noise
Abstract

Living organisms are exposed to potentially hazardous noise levels coming from the environment. Besides the direct effect on hearing, extra-auditory noise-associated effects should be considered. Since loud noise has been suggested to induce central nervous system symptoms, the aim of the present work was to investigate the effect of acute (ANE) and chronic noise exposures (CNE) on different behavioral tasks. To understand the mechanisms involved, levels of oxidative status markers were determined in two areas related to memory processes, the hippocampus (Hip) and the cerebellum (CE). 15-day-old male Wistar rats were exposed to loud noise (95-97 dB, 2 h/day), at ANE or CNE. At 30 days, rats were subjected to different CE and Hip-related behavioral tasks. Reactive oxygen species (ROS) levels and antioxidant enzyme activities (CAT and SOD) were also assessed. Results show impairments in spatial and associative memory in noise-exposed animals. Moreover, a decrease in anxiety levels and an increase in habituation memory were observed in CNE animals. While an increase in cerebellar ROS levels was found early after the first noise exposure, a decrease was found in the CE and the Hip at 30 days. The activity of hippocampal CAT was increased early and remained high in ANE rats, while it was unchanged in the CE. Finally, although SOD activity was decreased immediately after the first noise exposure, its levels were increased at 30 days in ANE rats. In summary, the present study shows that an imbalance in oxidative status induced by noise exposure could underlie behavioral changes, some of which would be long-lasting. Fil: Urán, Soledad Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Cáceres, Lucila Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Guelman, Laura Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina

Published
2010

2. Sex-dependent effects of short-term ethanol, energy drinks and acute noise exposure on hippocampal oxidative balance and glutamate transporter EAAT-1 during rat adolescence.

Author

Molina SJ, Corsi GN, Araujo Añon LC, and Guelman LR

Subjects
Animals, Male, Female, Rats, Noise adverse effects, Sex Characteristics, Excitatory Amino Acid Transporter 3, Hippocampus metabolism, Hippocampus drug effects, Rats, Wistar, Oxidative Stress drug effects, Ethanol administration & dosage, Ethanol toxicity, Reactive Oxygen Species metabolism, Excitatory Amino Acid Transporter 1 metabolism
Abstract

It is known that human adolescents often consume ethanol (EtOH) alone or mixed with energy drinks (ED), especially in noisy environments. Although these agents impact the developing brain, their effects after brief exposure or when presented together remain unclear. Given that few animal studies in this subject are available, this research aimed to study the effects of a brief exposure to these stimuli on the oxidative state and EAAT-1 glutamate transporter levels in the developing rat hippocampus (HC). Adolescent Wistar rats were subjected to a two-bottle choice, limited access to drinking in the dark paradigm, for EtOH and EtOH+ED intake, for 4 days, and subsequent acute noise exposure. Next, hippocampal catalase activity, reactive oxygen species (ROS), glutaredoxin-1 (Grx-1) and glutamate transporter EAAT-1 levels were assessed. Results showed sex-dependent alterations after exposure to these stimuli: Females consuming EtOH had higher hippocampal ROS levels, which decreased when combined with noise; males showed reduced ROS levels only after noise exposure. No significant changes occurred in catalase activity, Grx-1, or EAAT-1 levels with EtOH and noise exposure in neither sex. Additionally, ED raised EtOH consumption in both sexes, normalizing ROS levels only in females when combined with EtOH. Finally, ED consumption altered Grx-1 and EAAT-1 levels in both sexes. In summary, brief exposure to these stimuli induced sex-dependent alterations, suggesting differentiated coping strategies between sexes. Whereas ED consumption may have antioxidant effects in some cases, it could also increase excitotoxicity risk. These novel findings raise questions for future research on the underlying corresponding mechanisms., Competing Interests: Declaration of Competing Interest All authors declare that they have no conflicts of interest., (Copyright © 2024 Elsevier B.V. All rights reserved.)

Published
2024
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