1. Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia
- Author
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Heinrich Sauer, Franziska Degenhardt, Stephanie H. Witt, Ina Giegling, Manuel Mattheisen, Thomas W. Mühleisen, Jens Treutlein, Sandra Meier, Sven Cichon, Stefan Herms, Jana Strohmaier, Marcella Rietschel, Markus M. Nöthen, Per Hoffmann, Dan Rujescu, Thomas G. Schulze, Margrieta A. Alblas, and Igor Nenadic
- Subjects
Adult ,Male ,Candidate gene ,Genotype ,Schizophrenia (object-oriented programming) ,Single-nucleotide polymorphism ,Nerve Tissue Proteins ,Biology ,Polymorphism, Single Nucleotide ,Linkage Disequilibrium ,03 medical and health sciences ,0302 clinical medicine ,Gene Frequency ,Germany ,Genetic variation ,Humans ,SNP ,Genetic Predisposition to Disease ,ddc:610 ,International HapMap Project ,Genetic Association Studies ,Biological Psychiatry ,030304 developmental biology ,SV2A ,Genetics ,0303 health sciences ,Membrane Glycoproteins ,Haplotype ,Middle Aged ,SV2A protein, human ,Psychiatry and Mental health ,Schizophrenia ,Female ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value = 0.0042, OR = 0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.
- Published
- 2012