1. Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides.
- Author
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Zanatta N, Alves SH, Coelho HS, Borchhardt DM, Machado P, Flores KM, da Silva FM, Spader TB, Santurio JM, Bonacorso HG, and Martins MA
- Subjects
- Amides chemistry, Antifungal Agents chemistry, Fungi classification, Fungi drug effects, Magnetic Resonance Spectroscopy, Microbial Sensitivity Tests, Models, Molecular, Quantitative Structure-Activity Relationship, Spectrometry, Mass, Electrospray Ionization, Amides chemical synthesis, Amides pharmacology, Antifungal Agents chemical synthesis, Antifungal Agents pharmacology, Furans chemistry
- Abstract
The synthesis and characterization of a new series of furan-3-carboxamides, from the aromatization of 4-trichloroacetyl-2,3-dihydrofuran to 3-trichloroacetyl furan followed by nucleophilic displacement of the trichloromethyl group or the corresponding carboxylic acid chloride by nitrogen-containing compounds, is presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including yeast, filamentous fungi, bacteria, and alga. Some of the furan-3-carboxamides exhibited significant in vitro antimicrobial activity. QSAR investigation was applied to find a correlation between the different physicochemical parameters of the compounds studied and their biological activity.
- Published
- 2007
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