1. Identification of m6A-related lncRNAs LINC02471 and DOCK9-DT as potential biomarkers for thyroid cancer.
- Author
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Chen D, Zhao H, Guo Z, Dong Z, Yu Y, Zheng J, Ma Y, Sun H, Zhang Q, Zhang J, He Y, and Song T
- Subjects
- Female, Humans, Male, Middle Aged, Adenosine analogs & derivatives, Adenosine metabolism, Gene Expression Regulation, Neoplastic, GTPase-Activating Proteins genetics, GTPase-Activating Proteins metabolism, Prognosis, Biomarkers, Tumor genetics, RNA, Long Noncoding genetics, RNA, Long Noncoding metabolism, Thyroid Neoplasms genetics, Thyroid Neoplasms immunology
- Abstract
Thyroid cancer (THCA) is the most common endocrine malignancy worldwide and has been rising at the fastest rate in recent years. Long-stranded non-coding RNAs (lncRNAs) and N6-methyladenosine (m6A) have been associated with immunotherapy efficacy and cancer prognosis. However, how m6A-associated lncRNAs (mrlncRNAs) affect the prognosis of patients with thyroid cancer is unclear. Therefore, this study utilized The Cancer Genome Atlas (TCGA) database to provide thyroid cancer-related transcriptomic data and related clinical data. The R program was used to identify m6A-related lncRNAs, and a risk model consisting of two lncRNAs (LINC02471 and DOCK9-DT) was obtained using least absolute shrinkage and selection operator (LASSO) Cox regression analysis. Kaplan-Meier survival analysis and transient subject operating characteristics (ROC) were used for analysis. The results showed a substantial association between immune cell infiltration and risk scores. Independent analyses confirmed that the expression of LINC02471 and DOCK9-DT was significantly higher in thyroid cancer tissues than in normal tissues, suggesting that they may be useful biomarkers for thyroid cancer., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
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