1. Characterization and quantification of chlordecone elimination in ewes.
- Author
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Saint-Hilaire M, Fourcot A, Bousquet-Mélou A, Rychen G, Thomé JP, Parinet J, Feidt C, and Fournier A
- Subjects
- Animals, Chlordecone blood, Chlordecone urine, Feces chemistry, Female, Insecticides blood, Insecticides urine, Sheep, Soil Pollutants blood, Soil Pollutants urine, Chlordecone pharmacokinetics, Insecticides pharmacokinetics, Soil Pollutants pharmacokinetics
- Abstract
To reduce the exposure of the French West Indies population to the organochlorine insecticide chlordecone (Kepone; CLD), the contamination of currently consumed foodstuffs must be reduced. Depuration of contaminated animals before slaughter could be a strategy to obtain safe animal products. The aim of this study was to characterize and quantify CLD elimination in contaminated ewes during depuration process. Experiments A and B consisted in a single intravenous (i.v.) administration of CLD (n = 5) and CLDOH (chlordecol; n = 3) followed by a 84-d and 3-d depuration period respectively with collection of blood, faeces and urine samples. After CLD administration, CLD and conjugated-CLDOH (CLDOH-C) were quantified in serum and urine and CLD and CLDOH were quantified in faeces. Based on calculations of faecal, urinary and body clearances of CLD and CLDOH-C, faeces appeared as the major route of CLD excretion with 86 % of the CLD administered dose eliminated in faeces, either as CLD (51 %) or as CLDOH (35 %)., (Copyright © 2021. Published by Elsevier B.V.)
- Published
- 2021
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