1. Urine osmolality, cyclic AMP and aquaporin-2 in urine of patients under lithium treatment in response to water loading followed by vasopressin administration
- Author
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Antoine C. G. Egberts, Jan H. M. van Laarhoven, Alfred J. Apperloo, Kris L. L. Movig, Willem A. Nolen, Eibert R. Heerdink, Nine V A M Knoers, Ruben Baumgarten, Ingeborg Wilting, Population-based studies of drug treatment: from molecule to patient outcomes, Dep Farmaceutische wetenschappen, and Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)
- Subjects
Male ,Vasopressin ,Epidemiology ,vasopressin ,aquaporin-2 ,Membrane transport and intracellular motility [NCMLS 5] ,Diabetes Insipidus, Nephrogenic ,Urine ,Biomedische technologie en medicijnen ,Farmacie/Biofarmaceutische wetenschappen (FARM) ,Antimanic Agents ,Deamino Arginine Vasopressin ,Renal disorder [IGMD 9] ,Ziekenhuisstructuur en organisatie van de gezondheidszorg ,Kidney ,EXCRETION ,Geneeskunde (GENK) ,Farmacie(FARM) ,TREATED PATIENTS ,Middle Aged ,INDUCED POLYURIA ,medicine.anatomical_structure ,lithium ,Urine osmolality ,Lithium Compounds ,Female ,Public Health ,INDUCED NDI ,Adult ,medicine.medical_specialty ,RENAL-FUNCTION ,Health aging / healthy living [IGMD 5] ,Urinary system ,RATS ,Excretion ,KIDNEY ,nephrogenic diabetes insipidus ,Internal medicine ,medicine ,Humans ,cyclic AMP ,Geneeskunde(GENK) ,Aged ,Pharmacology ,Aquaporin 2 ,business.industry ,Osmolar Concentration ,Water ,Nephrogenic diabetes insipidus ,medicine.disease ,General [Econometric and Statistical Methods] ,Endocrinology ,Genetic defects of metabolism [UMCN 5.1] ,NEPHROGENIC DIABETES-INSIPIDUS ,Diabetes insipidus ,ALTERED EXPRESSION ,business ,HEALTHY-VOLUNTEERS - Abstract
Lithium is the drug that is most frequently associated with acquired nephrogenic diabetes insipidus (NDI). The exact mechanism of lithium-induced NDI in man is unknown. The aim of the present study was to investigate the kidney response to minimal and maximal stimulation of the kidney urine concentrating mechanism by measuring urine osmolality, and urine levels of cAMP and AQP-2 in urine of patients under long-term lithium treatment.Twenty patients under long-term lithium treatment were included. The kidney urinary 3',5'-cyclic adenosine monophosphate (cyclic AMP), aquaporin-2 levels and urine osmolality were determined during a situation of minimal kidney urine concentrating activity (induced by water loading) and during a situation following maximal stimulation of kidney urine concentrating activity (induced by 1-desamino-8-D-arginine-vasopressin).Patients were classified as NDI, partial NDI and non-NDI based on maximal reached urine osmolality. The partial correlation (r) between urinary cyclic AMP levels (mol/l) and urine osmolality was 0.94 (P In conclusion we found that in lithium-induced kidney urine concentrating deficit in man, the cyclic AMP generation in response to 1-desamino-8-D-arginine-vasopressin administration after water loading, is impaired. It remains to be elucidated whether principal cells, G-proteins or adenylate cyclase e.g. are the major targets for the mechanism underlying lithium-induced NDI in man. (c) 2007 Elsevier B.V. All rights reserved.
- Published
- 2007