1. A Case Report of Breakthrough Infections With 2 SARS-CoV-2 Variants in a Lung Transplant Patient.
- Author
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Mahan LD, Mohanka MR, Joerns J, Lawrence A, Bollineni S, Kaza V, Timofte I, La Hoz RM, Sorelle J, Terada LS, Kershaw CD, Torres F, and Banga A
- Subjects
- Humans, SARS-CoV-2, Breakthrough Infections, COVID-19, Lung Transplantation adverse effects
- Abstract
A lung transplant (LT) patient developed 2 distinct episodes of COVID-19, confirmed by whole-genome sequencing, which was caused by the Delta, and then followed 6 weeks later, by the Omicron variant. The clinical course with Omicron was more severe, leading us to speculate that Omicron may not be any milder among LT patients. We discuss the potential mechanisms behind the Omicron not being any milder among LT patients and emphasize the need for outcomes data among these patients. Until such data become available, it may be prudent to maintain clinical equipoise as regards the relative virulence of the newer variants among LT patients., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
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