1. Postreperfusion Biopsy as a Predictor of Biliary Complication After Deceased Donor Liver Transplantation. A Retrospective Cohort Study.
- Author
-
Fuentes-Valenzuela E, Sánchez-Delgado L, Maroto-Martín C, Juan-Casamayor L, Fernández-Prada S, Rodríguez MM, Tejedor-Tejada J, Rubiales BM, Alonso-Martín C, Peñas-Herrero I, Álvarez CA, and García-Pajares F
- Subjects
- Humans, Retrospective Studies, Living Donors, Risk Factors, Biopsy adverse effects, Postoperative Complications diagnosis, Postoperative Complications etiology, Postoperative Complications epidemiology, Liver Transplantation adverse effects, Reperfusion Injury diagnosis, Reperfusion Injury etiology
- Abstract
Background: Ischemia reperfusion injury (IRI) on postreperfusion biopsies is associated with worse outcomes after liver transplantation, although the influence on biliary complications (BC) remains poorly studied. Therefore, the primary aim of our study was to assess the influence of IRI on the incidence of BC. A secondary aim was to assess the influence of steatosis on biliary complications and determine factors that predictor BC., Methods: We report a retrospective cohort study including patients with liver transplantation and postreperfusion injury. Biopsies were classified as relevant and nonrelevant ischemia reperfusion injury for assessment of BC. BC included anastomotic stricture, ischemic cholangiopathy, leaks, and bilomas. Independent predictive factors of biliary complications were assessed using univariate and multivariate analyses., Results: 302 patients were included, and 125 patients fulfilled the criteria for relevant IRI (41.4%). Worse IRI was not associated with biliary complications (42.5% vs 40.1%; P = .68), nor was liver graft steatosis associated with BC (40.5% vs 41.5%, P = .95). The median time until biliary complications did not differ between the 2 groups (2 months; interquartile range = 1-15 vs 3 months; interquartile range = 1-12.5; P = .18). Hepatic artery thrombosis (odds ratio [OR] = 3.4; 95% confidence interval [CI], 1.4-8.2; P = .004), older donor age (OR = 2.1; 95% CI, 1.1-4.1; P = .024), and prolonged cold ischemia time (OR = 1.9; 95% CI, 1.1-3.2) were independent factors of biliary complications., Conclusion: Severe IRI on the postreperfusion injury does not predict development of biliary complications., (Copyright © 2022 Elsevier Inc. All rights reserved.)
- Published
- 2022
- Full Text
- View/download PDF