1. Impact of age- and gender-specific cut-off values for the fecal immunochemical test for hemoglobin in colorectal cancer screening
- Author
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Cristina Alvarez-Urturi, Montserrat Andreu, Cristina Hernandez, Francisco Perez-Riquelme, Fernando Carballo, Akiko Ono, Jose Cruzado, Joaquín Cubiella, Vicent Hernandez, Carmen Gonzalez Mao, Elena Perez, Dolores Salas, Mercedes Andrés, Luis Bujanda, Isabel Portillo, Cristina Sarasqueta, Enrique Quintero, Juan Diego Morillas, Angel Lanas, Carlos Sostres, Josep Maria Augé, Antoni Castells, Xavier Bessa, Francisca Gonzalez-Rubio, Alberto Moya-Calvo, Mónica Polo-Tomas, Maria Pilar Roncales, Pilar Sebastian-Martínez, María Ángeles Valencia-Doblas, Nieves Valero-Capilla, María E. Alkiza, Jone Altzibar, Pilar Amiano, Juan Arenas, Edurne Artiñano, Angel Cosme, Isabel Egitegi, Kepa Elorriaga, Jose L. Elósegui, José M. Enriquez-Navascués, Cristina Erce, Inés Gil, María A. Gutiérrez-Stampa, Marta Herreros, Elizabeth Hijona, Mariluz Jaúregui, Eva Laredo, Roberto Martínez, Maria J. Mitxelena, Isabel Montalvo, Carlos Placer, Onofre Alarcón, Inmaculada Alonso-Abreu, Marta Carrillo-Palau, Mariola de la Vega-Prieto, María Luisa Díez-Fuentes, Antonio Gimeno-García, Yanira González-Méndez, Manuel Hernández-Guerra, Renata Linertová, David Nicolás-Perez, Juana María Reyes-Melián, Cristina Álvarez, Josep M. Augé, Francesc Balaguer, Mercè Barau, Felipe Bory, Andrea Burón, Xavier Castells, Mercè Comas, Míriam Cuatrecasas, Maria Estrada, Olga Ferrer, Imma Garrell, Jaume Grau, Rafael Guayta, Cristina Hernández, María López-Cerón, Francesc Macià, Leticia Moreira, Teresa Ocaña, Maria Pellisé, Mercè Piracés, Sandra Polbach, Marc Puigvehí, Cristina Rodríguez, Maria Sala, Agustín Seoane, Anna Serradesanferm, Judith Sivilla, Mª Belén Aguado, Susana Aldecoa, Raquel Almazán, Ana Alonso, Inés Castro, Estela Cid, Lucía Cid, Joan Clofent, Mª Luisa de Castro, Pamela Estévez, Ana Belén Fernández, Mª Dolores González, Simoneta González, Mª Carmen González-Mao, Vicent Hernández, Begoña Iglesias, Felipe Iglesias, Pilar Iglesias, Ángeles López-Martínez, Ramiro Macenlle, Alfonso Martínez, David Martínez, Carlos Menéndez, Carmen Méndez, José Antonio Hermo, Isabel Pérez, Carmen Portasany, Mar Rionda, Concepción Rivera, Benito Rodríguez, Rosa Rodríguez, Manuel Rubio, María Isolina Santiago, Miriam Vázquez, José Ángel Vázquez, Pablo Vega, Mª Carmen Vidal, Raquel Zubizarreta, Luís Abreu, Francisco Javier Amador, Manuel Arroyo, Fernando Bandrés, Margarita Barba, José Manuel Blanco, Guillermo Cacho, José Cantero, Juan Carrasco, Beatriz Carrascosa, Gregorio Castellano, Francisco Colina, María Chaparro, Manuel Díaz-Rubio, José Díaz-Tasende, José Miguel Esteban, Conrado Fernández, Servando Fernández-Díez, Marta Fernández-Gil, Juan Ferrándiz, Alejandro Franco, Gabriela García-Álvarez, Aurelio Garrido, Sofía Garrido, Javier P. Gisbert, Mariano Gómez-Haba, Inés Gómez-Molíns, Andrés González-Navarro, María José González, Belén Herranz, Pilar Herránz, Alberto Herreros, Rosario Iglesias, Sonia Izquierdo, Carlos López, María Aranzazu López-Rubio, Alicia Marín, José Carlos Marín, María Carmen Martín, José Luis Martínez, Raquel Martínez, Carmen Moliner, José Manuel Moreno, Ricardo Moreno, Amelia Nogueiras, María Teresa Pérez, Rafael Píriz, Carmen Plaza, Elena Polentinos, Carmen Povés, Pedro Ruíz, Inmaculada Salces, Francisco Sánchez-Ceballos, Cecilio Santander, Rocío Sastre, Vicente Valentín, Miriam Alajarín, Fernando Alberca, Juan Bermejo, Joaquín Carrillo, José Cruzado, Purificación López, Mariano Martínez, María Dolores Navarro, Soledad Parra, Francisco Pérez-Riquelme, Consuelo Calvo, Montserrat Jimenez, Araceli Málaga, Elena Pérez, Antonio Peris, Marta Ponce, Rodrigo Jover, Teresa Sala, and Gloria Teruel
- Subjects
Adenoma ,Male ,Gerontology ,medicine.medical_specialty ,Colorectal cancer ,Population ,Colonoscopy ,Feces ,Hemoglobins ,03 medical and health sciences ,Sex Factors ,0302 clinical medicine ,Predictive Value of Tests ,Reference Values ,Internal medicine ,Humans ,Medicine ,education ,Early Detection of Cancer ,Aged ,Randomized Controlled Trials as Topic ,Retrospective Studies ,Immunoassay ,education.field_of_study ,Hepatology ,medicine.diagnostic_test ,business.industry ,Immunochemistry ,Carcinoma in situ ,Age Factors ,Gastroenterology ,Retrospective cohort study ,Middle Aged ,medicine.disease ,digestive system diseases ,030220 oncology & carcinogenesis ,Predictive value of tests ,Female ,030211 gastroenterology & hepatology ,Hemoglobin ,Colorectal Neoplasms ,business ,Carcinoma in Situ - Abstract
Background: There is no information on the impact of age and gender on the diagnostic yield of different positivity thresholds for the fecal immunochemical test for hemoglobin (FIT). Objectives: To evaluate the performance of this test at distinct positivity cut-offs in a population -based colorectal cancer (CRC) screening program. Methods: CRC detection rate (DR), and analysis of resources were evaluated retrospectively, at different cut-offs of FIT (20, 25, 30, 35 and 40 tig Hb/g) respect to a reference value (15 tig Hb/g), according to age and gender, in a screening population of 10,611 participants of the ColonPrev study (Quintero. NEJM 2013). Results: At the reference cut-off value, 36 CRC and 252 advanced adenomas (AA) were diagnosed. Increasing the cut-off in women 60 years increasing cut-off at 25-30 tig Hb/g. In men >60 years, all increases in the cut-off affected the CRC DR, especially when the cut-off was increased from 35 to 40 tig Hb/g (CRC miss rate 25%). Conclusions: To improve the performance of FIT in CRC screening programs, FIT cut-offs could be individualized by age and gender. (C) 2016 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
- Published
- 2016