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Purpose: To perform a meta-analysis comparing ultrasonography (US), US guided fine needle aspiration cytology (USgFNAC), computed tomography (CT), and magnetic resonance imaging (MRI) in the detection of lymph node metastases in head and neck cancer., Methods: MEDLINE, EMBASE and Cochrane databases were searched (January 1990-January 2006) for studies reporting diagnostic performances of US, USgFNAC, CT, and MRI to detect cervical lymph node metastases. Two reviewers screened text and reference lists of potentially eligible articles. Criteria for study inclusion: (1) histopathology was the reference standard, (2) primary tumors and metastases were squamous cell carcinoma and (3) data were available to construct 2 x 2 contingency tables. Meta-analysis of pairs of sensitivity and specificity was performed using bivariate analysis. Summary estimates for diagnostic performance used were sensitivity, specificity, diagnostic odds ratios (DOR) (95% confidence intervals) and summary receiver operating characteristics (SROC) curves., Results: From seventeen articles, 25 data sets could be retrieved. Eleven articles studied one modality: US (n=4); USgFNAC (n=1); CT (n=3); MRI (n=3). Six articles studied two or more modalities: US and CT (n=2); USgFNAC and CT (n=1); CT and MRI (n=1); MRI and MRI-USPIO (Sinerem) (n=2); US, USgFNAC, CT and MRI (n=1). USgFNAC (AUC=0.98) and US (AUC=0.95) showed the highest areas under the curve (AUC). MRI-USPIO (AUC=0.89) and CT (AUC=0.88) had similar results. MRI showed an AUC=0.79. USgFNAC showed the highest DOR (DOR=260) compared to US (DOR=40), MRI-USPIO (DOR=21), CT (DOR=14) and MRI (DOR=7). Conclusion USgFNAC showed to be the most accurate imaging modality to detect cervical lymph node metastases.

Objective: The clinical breast tumour size can be assessed preoperatively by physical examination, mammography and ultrasound. At present it is not clear which modality correlates best with the histological invasive breast tumour size. This prospective study aims to determine the most accurate clinical method (physical examination, mammography or ultrasound) to predict the histological invasive tumour size preoperatively., Methods and Patients: Between October 1999 and August 2000, 96 women with 105 invasive malignant breast tumours were included in this study. All patients underwent excision and the tumour size was measured on histology. Tumour size was measured by all three modalities in 73 cases. Results were evaluated by calculating correlation coefficients. The examination modalities presenting the best estimation of the pathological tumour size were used in a stepwise linear regression analysis to construct a formula predicting the pathological tumour size from the result of the various diagnostic modalities., Results: The correlation coefficient between ultrasound and pathological size (r=0.68) was significantly better than the correlations between physical examination and pathological size (r=0.42) and mammographic and pathological size (r=0.44). Physical examination overestimates and ultrasound underestimates breast tumour classification. The most accurate prediction formula was: Pathological tumour size (mm) equals sonographic tumour size (mm)+3 mm., Conclusion: When comparing physical examination, mammography and ultrasound for the prediction of the pathological size of a malignant breast tumour, ultrasound is the best predictor. The ensuing regression formula determines pathological size as tumour size by ultrasound+3 mm. However, with the wide 95% confidence interval of +/-11 mm, it remains difficult to predict the exact pathological size for an individual invasive breast tumour. A small deviation in millimetres of the tumour size could lead to a change in treatment and to another prognostic estimate.

Study Objectives: to study the validity and observers consistency in the detection of lung cancer on the chest radiograph., Materials and Methods: the chest radiographs of 100 clinical cases were interpreted by 14 observers. The radiographs were obtained from 30 patients with initially missed but histopathologically proven non-small cell lung cancer (NSCLC), 35 patients with other cardiopulmonary diseases and 35 patients with no abnormalities. The observers consisted of ten experienced radiologists, two-experienced chest physicians and two residents in radiology. All observers were unaware of the study design. The validity and observer consistency was determined for each observer., Results: the mean sensitivity and specificity of the ten radiologists were 0.36 and 0.90. For the two chest physicians, the mean sensitivity and specificity were 0.29 and 0.96. For the two residents in radiology, mean sensitivity and specificity were 0.25 and 0.94. The mean interobserver kappa and mean intraobserver kappa for the radiologists were 0.38 and 0.54. For the two chest physicians, the mean interobserver kappa was 0.43, while the intraobserver kappa was 0.59. For the two residents in radiology, mean interobserver kappa was 0.35 and the intraobserver kappa was 0.42. There was no significant relation between the consistency parameters and validity parameters. The interobserver and intraobserver kappa values showed good correlation., Conclusion: the validity of the chest radiograph and observers consistency in the detection of nodular lung cancer varies widely. The level of experience is likely to influence the diagnostic performance.

Aim: Comparison of the diagnostic value of cinefluoroscopy and simple fluoroscopy in the detection of calcification in coronary arteries., Patients and Methods: Data were prospectively obtained from 143 patients in whom simple fluoroscopy as well as cinecoronary arteriography were performed. Excluded were patients with a previous myocardial infarction, a previous abnormal cinecoronary arteriogram and patients with unstable angina. With the coronary arteriogram as the gold standard, the likelihood ratios (LR) of simple fluoroscopy were determined, mismatches with cinefluoroscopy were analysed and Kappa, as a measure for inter-test agreement, was calculated., Results: The LRs with 95% confidence intervals for a positive and negative result were 5.3 (2.6-11.0) and 0.43 (0.28-0.69), respectively. There was a mismatch in 12 (8.3%) patients. Kappa with a 95% confidence interval was 0.90 (0.73-1.0)., Conclusions: Both test modalities are almost identical and conclusions with respect of the diagnostic value of cinefluoroscopy also holds for simple fluoroscopy.

Aim: To determine in which patients (cine)fluoroscopic detection of coronary artery calcifications is recommended for the diagnosis of coronary artery disease and the consequence of this finding for referral for cinecoronary arteriography., Materials and Methods: Data were retrospectively obtained from 778 patients who had been referred for cinecoronary arteriography. Excluded were patients with a previous myocardial infarction, a previous abnormal cinecoronary arteriogram and patients with unstable angina. The discriminating value was assessed with the help of the crude likelihood ratio (LR), as well as the LRs stratified for gender, age and symptomatology. The gold standard was the coronary arteriogram. Furthermore, the post-test probability was estimated using logistic regression to take dependence on age, sex and symptomatology into account., Results: The crude LR of a positive and negative test result, with 95% confidence intervals, was, respectively 5.8 (4.1-8.2) and 0.52 (0.47-0.58), but was dependent on the clinical variables. Estimated probabilities of having coronary artery disease (CAD) varied substantially for a negative as well as a positive test result with the categories of clinical variables., Conclusion: (Cine)fluoroscopy discriminates between patients with and without disease; the test proved to be especially useful in females with atypical angina and patients of both sexes with non-specific chest pain.

A survey was held into methods and extent of vascular radiology in the Netherlands. For the year 1992, quantitative data on the number of patients, vascular radiological examinations and characteristics of angiography facilities were obtained from more than 80% of the Dutch hospitals with angiography rooms (120). The following estimates have been inferred: approximately 50,600 patients were referred for non-cardiac vascular radiology, including 32,100 patients for intra-arterial arteriography, 8900 for intravenous DSA arteriography, 4600 for phlebography and 5000 for interventional radiology. On average about two vascular examinations were carried out per patient referred for arteriography. In interventional radiology, the number of patients and the number of examinations are quite similar. The total number of angiography rooms in the Netherlands was 136. The average age of angiography X-ray systems was 7.1 years, of imaging equipment 5.7 years. In 56% of the hospitals, the X-ray tube was normally applied in the undercouch position, in 40% in overcouch position and in 4% there was no preferred position. An additional survey of occupational exposure conditions in angiography rooms (19 hospitals) showed that, in most hospitals, protective lead aprons of 0.5 mm Pb-equivalent were in use. Thyroid collars were used rather infrequently.

In recent years the right gastroepiploic artery (GEA) has been used as an in situ graft in coronary artery bypass grafting (CABG). The specific anatomical course of the GEA graft enables the use of color Doppler imaging technique to evaluate its patency. The results in 21 patients demonstrate the efficiency of this technique; postoperative angiography to establish patency can therefore be avoided.

The CT and plain chest film abnormalities in eight patients with invasive pulmonary aspergillosis (IPA) are described and compared. The various radiologic findings of IPA were (sub)segmental and patchy consolidation, cavitation and an air crescent sign. CT had a higher sensitivity for multiplicity of lesions and cavitation compared with the plain chest film. Because these abnormalities are keypoints of the diagnosis, CT is recommended in patients suspected of IPA.