1. Discovery of potent CRTh2 (DP2) receptor antagonists.
- Author
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Birkinshaw TN, Teague SJ, Beech C, Bonnert RV, Hill S, Patel A, Reakes S, Sanganee H, Dougall IG, Phillips TT, Salter S, Schmidt J, Arrowsmith EC, Carrillo JJ, Bell FM, Paine SW, and Weaver R
- Subjects
- Chemistry, Pharmaceutical, Drug Design, Humans, Inhibitory Concentration 50, Models, Chemical, Protein Binding, Receptors, Prostaglandin metabolism, Asthma drug therapy, Indomethacin pharmacology, Inflammation drug therapy, Receptors, Immunologic antagonists & inhibitors, Receptors, Prostaglandin antagonists & inhibitors, Rhinitis drug therapy
- Abstract
Starting with the weak agonist indomethacin, a series of potent, selective CRTh2 (DP(2)) antagonists have been discovered as potential treatments for asthma, allergic rhinitis and other inflammatory diseases.
- Published
- 2006
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