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Contrast demodulation and phase distortions are exaggerated in retinal images blurred by the higher-order wavefront aberrations of keratoconic eyes. While the performance loss from the former parameter is well understood, little is known about the impact of the latter on visual functions in this disease condition. The present study investigated the impact of phase distortions on the monocular logMAR visual acuity, letter discriminability and random-dot stereoacuity of seventeen visually healthy adults (ten for visual acuity and letter discriminability; ten for stereoacuity and three common to both experiments) using images that were computationally blurred by four different higher-order wavefront aberration profiles of keratoconic eyes that showed significant distortions in the phase spectrum. Participants viewed these images through 2 mm artificial pupils to negate their native ocular wavefront aberrations. The results showed progressive losses in visual acuity and stereoacuity with increasing blur, a third of which could be recovered following phase nullification. Letter discriminability also improved following phase nullification, more so for smaller than larger optotypes. Stereoacuity loss and, consequently, its recovery following phase nullification was more prominent for profiles simulating unilateral asymmetric keratoconus than for profiles simulating bilateral symmetric keratoconus. These results agree with previous reports obtained from blur induced with lower-order aberrations and indicate that a similar trend may be observed for more complex patterns of blur like keratoconus. Overall, both contrast demodulation and misalignment of the local features of the blurred image may contribute to losses of spatial and depth vision in keratoconus. Phase nullification may partially mitigate these losses, thereby allowing the processing of finer spatial details and veridical disparity estimations for improved depth perception., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

When observers perceive 3D relations, they represent depth and spatial locations with the ground as a reference. This frame of reference could be egocentric, that is, moving with the observer, or allocentric, that is, remaining stationary and independent of the moving observer. We tested whether the representation of relative depth and of spatial location took an egocentric or allocentric frame of reference in three experiments, using a blind walking task. In Experiments 1 and 2, participants either observed a target in depth, and then straightaway blind walked for the previously seen distance between the target and the self; or walked to the side or along an oblique path for 3 m and then started blind walking for the previously seen distance. The difference between the conditions was whether blind walking started from the observation point. Results showed that blind walking distance varied with the starting locations. Thus, the represented distance did not seem to go through spatial updating with the moving observer and the frame of reference was likely allocentric. In Experiment 3, participants observed a target in space, then immediately blind walked to the target, or blind walked to another starting point and then blind walked to the target. Results showed that the end location of blind walking was different for different starting points, which suggested the representation of spatial location is likely to take an allocentric frame of reference. Taken together, these experiments convergingly suggested that observers used an allocentric frame of reference to construct their mental space representation., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Biological visual systems rely on pose estimation of 3D objects to navigate and interact with their environment, but the neural mechanisms and computations for inferring 3D poses from 2D retinal images are only partially understood, especially where stereo information is missing. We previously presented evidence that humans infer the poses of 3D objects lying centered on the ground by using the geometrical back-transform from retinal images to viewer-centered world coordinates. This model explained the almost veridical estimation of poses in real scenes and the illusory rotation of poses in obliquely viewed pictures, which includes the "pointing out of the picture" phenomenon. Here we test this model for more varied configurations and find that it needs to be augmented. Five observers estimated poses of sloped, elevated, or off-center 3D sticks in each of 16 different poses displayed on a monitor in frontal and oblique views. Pose estimates in scenes and pictures showed remarkable accuracy and agreement between observers, but with a systematic fronto-parallel bias for oblique poses similar to the ground condition. The retinal projection of the pose of an object sloped wrt the ground depends on the slope. We show that observers' estimates can be explained by the back-transform derived for close to the correct slope. The back-transform explanation also applies to obliquely viewed pictures and to off-center objects and elevated objects, making it more likely that observers use internalized perspective geometry to make 3D pose inferences while actively incorporating inferences about other aspects of object placement., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Rectangularity and perpendicularity of contours are important properties of 3D shape for the visual system and the visual system can use them asa prioriconstraints for perceivingshape veridically. The presentarticle provides a comprehensive review ofpriorstudiesofthe perception of rectangularity and perpendicularity anditdiscussestheir effects on3D shape perception from both theoretical and empiricalapproaches. It has been shown that the visual system is biased to perceive a rectangular 3D shape from a 2D image. We thought that this bias might be attributable to the likelihood of a rectangular interpretation but this hypothesis is not supported by the results of our psychophysical experiment. Note that the perception ofa rectangular shape cannot be explained solely on the basis of geometry. A rectangular shape is perceived from an image that is inconsistent with a rectangular interpretation. To address thisissue, we developed a computational model that can recover a rectangular shape from an image of a parallelopiped. The model allows the recovered shape to be slightly inconsistent so that the recovered shape satisfies the a priori constraints of maximum compactness and minimal surface area. This model captures someof thephenomenaassociated withthe perception of the rectangular shape that were reported inpriorstudies. This finding suggests that rectangularity works for shape perception by incorporatingitwith someadditionalconstraints., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Some animals including humans use stereoscopic vision which reconstructs spatial information about the environment from the disparity between images captured by eyes in two separate adjacent locations. Like other sensory information, such stereoscopic information is expected to influence attentional selection. We develop a biologically plausible model of binocular vision to study its effect on bottom-up visual attention, i.e., visual saliency. In our model, the scene is organized in terms of proto-objects on which attention acts, rather than on unbound sets of elementary features. We show that taking into account the stereoscopic information improves the performance of the model in the prediction of human eye movements with statistically significant differences., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Perception of motion in depth is one of the most important visual functions for living in the three-dimensional world. Two binocular cues have been investigated for motion in depth: inter-ocular velocity difference (IOVD) and changing disparity (CD). IOVD provides direction information directly by comparing velocity signals from the two retinas. In this study, we propose for the first time a motion-in-depth model of IOVD that predicts motion-in-depth direction. The model is based on a psychophysical assumption that there are four channels tuned to different directions in depth (Journal of Physiology 235 (1973) 17-29). We modeled these channels by combining outputs of low-level motion detectors that are sensitive to left and right retinal stimulation. Using these channels, we constructed a model of motion in depth that successfully predicted a variety of psychophysical results including direction discrimination, perceived direction, spatial frequency tuning, effect of speed on rotation in depth, effect of lateral motion direction, and effect of binocular and temporal correlations., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Many people with stereo-deficiency cannot perform stereoacuity tasks at any binocular disparity, so their threshold cannot be measured. We developed a generally useful new composite stereodepth or CSD score, with range 0 to 20, that combines stereoacuity (from 0 to 13.3) and percent correct (13.3 to 20) into a single index. CSD allows differences in stereodepth performance to be measured across groups when thresholds cannot be reliably measured, and across time when individuals gain stereodepth perception during training. We used CSD scores to assess the benefit of unequal (mixed) left- and right-eye contrast during dichoptic stereoacuity training in people with amblyopia. Nineteen adult participants with anisometropic amblyopia were assigned randomly to 10 sessions of either mixed-contrast or fixed-contrast training. Stimuli were rectangles, one above the other, viewed through a four-mirror stereoscope. Participants indicated which rectangle appeared closer. A staircase controlled disparity within the stimulus. CSD improvement was better by 1.6 CSD units for participants who received mixed-contrast training. Thus, mixed-contrast stereo training was more effective than fixed-contrast training in adults with anisometropic amblyopia., (Copyright © 2019. Published by Elsevier Ltd.)

Stereoscopic, or "3D" vision in humans is mediated by neurons sensitive to the disparities in the positions of objects in the two eyes' views. A disparity-sensitive neuron is typically characterized by its responses to left- and right-eye monocular signals, S L and S R , respectively. However, it can alternatively be characterized by sensitivity to the sum of the two eyes' inputs, S +  = S L  + S R , and the difference, S -  = S L  - S R . Li and Atick's theory of efficient binocular encoding proposes that the S + and S - signals can be separately weighted to maximize the efficiency with which binocular information is encoded. This adaptation changes each neuron's sensitivity and preferred binocular disparity, resulting in predicted effects on the perceived stereoscopic depth of objects. To test these predictions, we measured the apparent depth of a random-dot stereogram with an 'in-front' target following adaptation to binocularly correlated or anti-correlated horizontally-oriented grating stimuli, which reduce sensitivity to the S + and S - signals, respectively, but which contain no conventional stereo-depth signals. The anti-correlated noise adaptation made the target appear relatively closer to the background than the correlated noise adaptation, with differences of up to 60%. We show how this finding can be accommodated by a standard model of binocular disparity processing, modified to incorporate the binocular adaptation suggested by Li and Atick's theory., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

New digital approaches allow stereovision to be assessed with greater precision than current clinical stereo tests. Those current tests present a relatively narrow range of stimulus disparities in coarsely quantized steps. With dichoptic treatments for amblyopia emerging, more accurate assessment of especially coarse stereopsis becomes increasingly important for verifying their aim to improve 3D vision. We used digital testing in subjects of a large age range (4-59 years), with groups having both normal (n = 34) and impaired binocular vision due to unilateral amblyopia, with or without strabismus (n = 27). Random-dot stimuli were presented on a 3D monitor with shutter glasses. The test applies adaptive procedures to measure psychometric functions and provides thresholds with associated confidence intervals. Digital thresholds for controls (range 11-160 arcsec) and stereodeficient subjects (range 43-911 arcsec) were compared to the TNO, a standard clinical test which uses similar random-dot targets presented with anaglyph glasses. Agreement between digital and TNO thresholds varied with the level of stereopsis. Stereoacuity was measurable in several subjects who failed on the TNO. With the digital test we found good repeatability for both groups, with the indication of a small learning effect for subjects with coarse stereopsis. Thus, assessment of all target groups for new tests is important, and repeated testing before therapy may avoid confusing learning and treatment effects. Our digital approach supplies a large range of accurate stereo data in children and adults; together with its associated measure of variability, it will be useful in longitudinal treatment studies., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Stereoscopic three-dimensional vision requires cortical processing for horizontal binocular disparity between the two eyes' retinal images. Behavioral and theoretical studies suggest that vertical size disparity is used to recover the viewing geometry and to generate the slant of a large surface. However, unlike horizontal disparity, the relation between stereopsis and neural responses to vertical disparity remains controversial. To determine the role of cortical processing for vertical size disparity in stereopsis, we measured neuromagnetic responses to disparities in people with good and poor stereopsis, using magnetoencephalography (MEG). Healthy adult participants viewed stereograms with a horizontal or vertical size disparity, and judged the perceived slant of the pattern. We assessed neural activity in response to disparities in the visual cortex and the phase locking of oscillatory responses including the alpha frequency range using MEG. For participants with good stereopsis, activity in the visual areas was significantly higher in response to vertical size disparity than to horizontal size disparity. The time-frequency analysis revealed that early neural responses to vertical size disparity were more phase-locked in good stereo participants than in poor stereo participants. These results provide neuromagnetic evidence that vertical-size disparity processing plays a role in good stereo vision., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Amblyopia is associated with a range of well-known visual spatial deficits, which include reduced contrast sensitivity, spatial distortions, interocular suppression, and impaired stereopsis. Previous work has also pointed to deficits in processing dynamic visual information, but it is unknown whether these deficits influence performance under binocular conditions. We examined the effects of temporal modulation on contrast sensitivity and binocular interactions in a preliminary study of 8 adults with amblyopia and 14 normally-sighted control subjects. For each observer, we measured interocular balance and stereopsis thresholds with binocular flicker across a range of four temporal (0, 4, 7.5, and 12 Hz) and spatial (1, 2, 4, and 8 cpd) frequencies. Interocular balance was estimated by varying the relative contrast of dichoptic letter pairs to produce perceptual reports of each letter with equal frequency, and stereopsis thresholds were measured by determining the minimum disparity at which subjects identified a front-depth target with 75% accuracy. Consistent with previous findings, we observed greater interocular imbalance and impaired stereoacuity at high spatial frequencies in amblyopes. In contrast, the effects of temporal frequency on performance were smaller: across both groups, interocular imbalance was largest at mid-to-low temporal frequencies, and stereopsis thresholds were unaffected by temporal frequency. Our results suggest that there may be a previously unreported effect of temporal frequency on interocular balance, as well as a possible dissociation between the effects of flicker on interocular balance and stereopsis., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

In a series of studies using physical targets, we examined the effect of lateral retinal motion on stereoscopic depth discrimination thresholds. We briefly presented thin vertical lines, along with a fixation marker, at speeds ranging from 0 to 16 deg·s -1 . Previous investigations of the effect of retinal motion on stereoacuity consistently show that there is little impact of retinal motion up to 2 deg·s -1 , however, thresholds appear to rise steeply at higher velocities (greater than 3 deg·s -1 ). These prior experiments used computerized displays to generate their stimuli. In contrast, with our physical targets we find that stereoacuity is stable up to 16 deg·s -1 , even in the presence of appreciable smearing due to visual persistence. We show that this discrepancy cannot be explained by differences in viewing time, prevalence of motion smear or by high frequency flicker due to display updates. We conclude that under natural viewing conditions observers are able to make depth discrimination judgements using binocular disparity signals that are rapidly acquired at stimulus onset., (Copyright © 2019 Elsevier Ltd. All rights reserved.)

Global context can dramatically influence local visual perception. This phenomenon is well-documented for monocular features, e.g., the Kanizsa triangle. It has been demonstrated for binocular matching: the disambiguation of the Wallpaper Illusion via the luminance of the background. For monocular features, there is evidence that global context can influence neuronal responses as early as V1. However, for binocular matching, the activity in this area of the visual cortex is thought to represent local processing, suggesting that the influence of global context may occur at later stages of cortical processing. Here we sought to test if binocular matching is influenced by contextual effects in V1, using fMRI to measure brain activity while participants viewed perceptually ambiguous "wallpaper" stereograms whose depth was disambiguated by the luminance of the surrounding region. We localized voxels in V1 corresponding to the ambiguous region of the pattern, i.e., where the signal received from the eyes was not predictive of depth, and despite the ambiguity of the input signal, using multi-voxel pattern analysis we were able to reliably decode perceived (near/far) depth from the activity of these voxels. These findings indicate that stereoscopic related neural activity is influenced by global context as early as V1., (Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Stereoscopic depth is most useful when it comes from relative rather than absolute disparities. However, the depth perceived from relative disparities can vary with stimulus parameters that have no connection with depth or are irrelevant to the task. We investigated observers' ability to judge the stereo depth of task-relevant stimuli while ignoring irrelevant stimuli. The calculation of depth from disparity differs for 1-D and 2-D stimuli and we investigated the role this difference plays in observers' ability to selectively process relevant information. We show that the presence of irrelevant disparities affects perceived depth differently depending on stimulus dimensionality. Observers could not ignore disparities of irrelevant stimuli when they judged the relative depth between a 1-D stimulus (a grating) and a 2-D stimulus (a plaid). Yet these irrelevant disparities did not affect judgments of the relative depth between 2-D stimuli. Two processes contributing to stereo depth were identified, only one of which computes depth from a horizontal disparity metric and permits attentional selection. The other uses all stimuli, relevant and irrelevant, to calculate an effective disparity direction for comparing disparity magnitudes. These processes produce inseparable effects in most data sets. Using multiple disparity directions and comparing 1-D and 2-D stimuli can distinguish them., (Copyright © 2019. Published by Elsevier Ltd.)

To further extent our understanding of aquatic vision, we introduce a complete optical model of a goldfish eye, which comprises all important optical parameters for the first time. Especially a spherical gradient index structure for the crystalline lens was included, thus allowing a detailed analysis of image quality, regarding spot size, and wavelength dependent aberration. The simulation results show, that our realistic eye model generates a sufficient image quality, with a spot radius of 4.9 μm which is below the inter cone distance of 5.5 μm. Furthermore, we optically simulate potential mechanical processes of accommodation and compare the results with contradictory findings of previous experimental studies. The quantitative simulation of the accommodation capacity shows that the depth of field is strongly dependent on the resting position and becomes significantly smaller when shorter resting positions are assumed. That means, to enable an extended depth perception with high acuity for the goldfish an adaptive, lens shifting mechanism would be required. In addition, our model allows a clear prediction of the expected axial lens-shift, which is necessary to ensure a sufficient resolution over a large object range., (Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

School aged children with progressive myopia show large accommodative lags to blur only cue which is suggestive of a large depth of focus (DOF). While DOF measures are lacking in this age group, their blur detection and discrimination capacities appear to be similar to their non-myopic peers. Accordingly, the current study quantified DOF and blur detection ability in progressive myopic children showing large accommodative lags compared to their non-myopic peers and adults. Blur sensitivity measures were taken from 12 children (8-13 years, 6 myopes and 6 emmetropes) and 6 adults (20-35 years). DOF was quantified using step changes in the lens induced defocus while the subjects viewed a high contrast target through a Badal lens at either 2 or 4D demand. Blur detection thresholds (BDT) were tested using a similar high contrast target in a 2-alternate forced-choice paradigm (2AFC) at both the demands. In addition to the large accommodative lags, micro fluctuations and DOF were significantly larger in myopic children compared to the other groups. However, BDTs were similar across the three groups. When limited to blur cues, the findings of a large DOF coupled with large response lags suggests that myopes are less sensitive to retinal defocus. However, in agreement to a previous study, refractive error had no influence on their BDTs suggesting that the reduced sensitivity to the defocus in a myopic eye appears to be compensated by some form of an adjustment in the higher visual processes to preserve the subjective percept even with a poor retinal image quality., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Ocular accommodation potentially provides information about depth but there is little evidence that this information is used by the human visual system. We use the hollow-face illusion, an illusion of depth reversal, to investigate whether accommodation is linked to perceived depth. In Experiment 1 accommodation, like vergence, was in front of the physical surface of the mask when the mask was upright and people reported experiencing the illusion. Accommodation to the illusory face did not differ significantly from accommodation to the physically convex back surface of the same mask. Only accommodation to the inverted mask seen as hollow was significantly less and, like the physical surface, beyond the mid-plane of the mask. The effect on accommodation was the same for monocular as binocular viewing, showing that accommodation is not driven by binocular disparities through vergence, although voluntary vergence remains a possibility. In Experiment 2 a projected random dot pattern was used to flip perception between convex and concave in all presentation conditions. Accommodation was again in front of the physical surface when the illusion was experienced. Experiment 3 showed that projected dots are more effective in disambiguating the illusion as concave when they are sharp and provide a good accommodative stimulus than when they are objectively blurred. We interpret Experiments 1 and 2 as showing that accommodation is tied to perceived depth, directly or indirectly, even in a situation where multiple depth cues are available and feedback is not artificially open-looped. Experiment 3 is consistent with accommodation helping to disambiguate depth while not ruling out alternative explanations., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

To investigate the effect of intraocular scatter on stereopsis, we measured stereoacuity with scatter either remaining at the natural eye-induced level or further enhanced by a set of three different scatter filters. Stereo thresholds at different viewing durations were obtained using a psychophysical method of constant stimuli. The results indicate that stereoacuity was degraded with a binocular increase in scatter levels for all the subjects. Measurements were also performed in the presence of interocular differences in scatter levels. In this case, stereoacuity was found to be even a little worse than that obtained with both eyes at a higher scatter level. This suggests that stereoacuity in the presence of interocular differences in scatter levels is mainly dependent on the higher scatter level., (Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

The current study examined whether the 'slow and smooth' hypothesis (Hildreth, 1984; Yuille & Grzywacz, 1989; Weiss, Simoncelli, & Adelson, 2002) could be extended to explaining a three-dimensional (3D) stereokinetic percept by specifying the smoothness term as a preference for minimal deformation. Stereokinetic stimuli are two-dimensional (2D) configurations that lead to 3D percepts when rotated in the image plane. In particular, a rotating ellipse with an eccentric dot gives rise to the percept of a cone with a defined height. In the current study, the spatial relationship between the ellipse and dot varied across trials in terms of the dot's relative location and the aspect ratio of the ellipse. During each trial, participants (n = 8) adjusted the length of a 2D bar centered along the minor axis of the ellipse to indicate their perceived height of the cone. Upon rotation, the 2D bar was perceived to be perpendicular to the circular base of the cone. Our results were qualitatively and quantitatively consistent with the traditional hypothesis of minimum object change (Jansson & Johansson, 1973), which is also similar to the maximal rigidity assumption (Ullman, 1979). As the dot shifted from the major axis towards the minor axis of the ellipse, observers consistently reported an increasingly taller cone. The results illustrate the tendency of observers to perceive the apex of the cone at a height that minimized its 3D distance to the surface normal at the center of the circular base of the cone to reduce the relative motion between the dot and the base of the cone. The current study provides empirical evidence suggesting that, when presented with an ambiguous stereokinetic stimulus, the visual system prefers the interpretation that corresponds to a 3D percept that is slowest and maximally rigid., (Copyright © 2018. Published by Elsevier Ltd.)

The visual system must transform a point-by-point biological representation from the photoreceptors into neural representations of separate objects. Even a uniform circular patch of light that slowly modulates in luminance can be segmented into separate central and surrounding areas merely by introducing black lines to outline a central square. The black lines cause brightness induction in the center even though the light inside and outside the square is always identical, as predicted by spatial antagonism between the square central area and its surround. Importantly, illusory Kanizsa lines forming the square are as effective for this brightness induction as real black lines, suggesting a 'form-cue invariant' cortical neural representation that does not distinguish between a central region set off by real or illusory edges. An open question is whether separate subsystems generate objects defined by real versus illusory edges, each providing the same form-cue invariant neural representation of an object, or whether form-cue invariance extends to integrating component pieces that together define an object. Experiments here show object segmentation when subparts of a square are defined by a mixture of real and illusory edges. Subjects adjusted the Michelson contrast of a separate patch to match the perceived modulation depth within the central region of a circular field that slowly oscillated in luminance. A closed, four-sided figure, no matter how constructed, reduced the perceived modulation depth within the central region. This shows that both real and illusory subparts can be integrated to segment center from surround. It supports a strong version of form-cue invariance in which neural mechanisms responsible for object segmentation are impartial to the piecemeal cues that are integrated to define an object., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

The visual system can represent a partially occluded 3-D surface from images of separated surface segments. The underlying amodal surface integration process accomplishes this by amodally extending each surface segment behind the occluder (amodal surface extension) and integrating the extended surfaces to form a whole surface representation. We conducted five experiments to investigate how depth cues, such as binocular disparity, half-occlusion, and monocular depth cues (T-junctions and L-junctions), contribute to amodal surface extension, and how the geometrical relationship and image similarity among the surface segments affect surface integration. This was achieved by having observers adjust the stereoscopic depth and slant of a comparison stimulus to match those of the tested 3-D stimulus. We found that both binocular disparity and half-occlusion cues are used to determine border-ownership assignment of surface segments and for amodal surface extension. We also found that separated surface segments need to have the same luminance contrast-polarity for them to be integrated as a whole surface. Finally, we found that having the same motion direction, minimum misalignment between boundary contours, and proximity among separated segments facilitate their integration. Overall, our findings reveal a set of "perceptual factors" for amodal surface integration, which arguably reflects our visual system's built-in knowledge of the regularities in natural scenes., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Macular degeneration results in heterogeneous central field loss (CFL) and often has asymmetrical effects in the two eyes. As such, it is not clear to what degree the movements of the two eyes are coordinated. To address this issue, we examined smooth pursuit quantitatively in CFL participants during binocular viewing and compared it to the monocular viewing case. We also examined coordination of the two eyes during smooth pursuit and how this coordination was affected by interocular ratios of acuity and contrast, as well as CFL-specific interocular differences, such as scotoma sizes and degree of binocular overlap. We hypothesized that the coordination of eye movements would depend on the binocularity of the two eyes. To test our hypotheses, we used a modified step-ramp paradigm, and measured pursuit in both eyes while viewing was binocular, or monocular with the dominant or non-dominant eye. Data for CFL participants and age-matched controls were examined at the group, within-group, and individual levels. We found that CFL participants had a broader range of smooth pursuit gains and a significantly lower correlation between the two eyes, as compared to controls. Across both CFL and control groups, smooth pursuit gain and correlation between the eyes are best predicted by the ratio of contrast sensitivity between the eyes. For the subgroup of participants with measurable stereopsis, both smooth pursuit gain and correlation are best predicted by stereoacuity. Therefore, our results suggest that coordination between the eyes during smooth pursuit depends on binocular cooperation between the eyes., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Threshold functions for sinusoidal depth corrugations typically reach their minimum (highest sensitivity) at spatial frequencies of 0.2-0.4 cycles/degree (cpd), with lower thresholds for horizontal than vertical corrugations at low spatial frequencies. To elucidate spatial frequency and orientation tuning of stereoscopic mechanisms, we measured the disparity sensitivity functions, and used factor analytic techniques to estimate the existence of independent underlying stereo channels. The data set (N = 30 individuals) was for horizontal and vertical corrugations of spatial frequencies ranging from 0.1 to 1.6 cpd. A principal component analysis of disparity sensitivities (log-arcsec) revealed that two significant factors accounted for 70% of the variability. Following Varimax rotation to approximate "simple structure", one factor clearly loaded onto low spatial frequencies (≤0.4 cpd), and a second was tuned to higher spatial frequencies (≥0.8 cpd). Each factor had nearly identical tuning (loadings) for horizontal and vertical patterns. The finding of separate factors for low and high spatial frequencies is consistent with previous studies. The failure to find separate factors for horizontal and vertical corrugations is somewhat surprising because the neuronal mechanisms are believed to be different. Following an oblique rotation (Direct Oblimin), the two factors correlated significantly, suggesting some interdependence rather than full independence between the two factors., (Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.)

A factor analysis was performed on 25 visual and auditory performance measures from 1060 participants. The results revealed evidence both for a factor relating to general perceptual performance, and for eight independent factors that relate to particular perceptual skills. In an unrotated PCA, the general factor for perceptual performance accounted for 19.9% of the total variance in the 25 performance measures. Following varimax rotation, 8 consistent factors were identified, which appear to relate to (1) sensitivity to medium and high spatial frequencies, (2) auditory perceptual ability (3) oculomotor speed, (4) oculomotor control, (5) contrast sensitivity at low spatial frequencies, (6) stereo acuity, (7) letter recognition, and (8) flicker sensitivity. The results of a hierarchical cluster analysis were consistent with our rotated factor solution. We also report correlations between the eight performance factors and other (non-performance) measures of perception, demographic and anatomical measures, and questionnaire items probing other psychological variables., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Motion-induced blindness (MIB; Bonneh, Cooperman, & Sagi, 2001) is a visual phenomenon in which salient, stationary high-contrast targets are perceived to disappear and reappear when viewed within a moving background mask. The present study examined the effects of depth ordering (three levels) and mask motion coherence (0%, 50%, and 100% coherence of the mask elements), as well as the interaction effects between these two variables, especially taking note of between-subject variation. It is clear that individuals experience different amounts of MIB, indexed using average, cumulative, and normalized measures. Other differences are exhibited in how depth order and levels of mask coherence affect individuals' perception of MIB. This study was able to partially replicate the depth ordering effects exhibited by Graf, Adams, and Lages (2002); however, we were unable to replicate the effects of mask coherence reported by Wells, Leber, and Sparrow (2011), and possible reasons are explored, including the possible role of adaptation. No significant interaction effect was found between depth order and coherence, suggesting these processes act independently of one another. Implications for between-subject variability are discussed. A single underlying parameter accounting for individual differences among observers was not identified, suggesting that normative models of MIB may not be practical., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

It is well known that small orientation differences between two monocular gratings fuse to generate a stereoscopic perception of tilt, while large differences trigger binocular rivalry. In addition, unequal monocular contrasts combine nonlinearly to generate binocular contrast. A nonlinear neural model is developed here to account for binocular contrast, fusion at small orientation differences, and rivalry at large differences. The model also accounts for hysteresis in the transition between fusion and rivalry. Finally, the model predicts that interocular contrast differences between fusible gratings will produce a reduced tilt percept, and experiments reported here support this. Key to the model is the presence of two classes of inhibitory interneurons: one operating on similar orientations to normalize interocular contrast (IN), and one operating across large orientation differences to generate rivalry (IR). Critically, the IN neurons switch off the IR neurons driven by the other eye, thus permitting fusion of binocular plaids., (Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

To successfully navigate throughout the world, observers must rapidly recover depth information. One depth cue that is especially important for a moving observer is motion parallax. To perceive unambiguous depth from motion parallax, the visual system must integrate information from two different proximal signals, retinal image motion and a pursuit eye movement. Previous research has shown that aging affects both of these necessary components for motion parallax depth perception, but no research has yet investigated how aging affects the mechanism for integrating motion and pursuit information to recover depth from motion parallax. The goal of the current experiment was to assess the integration time required by older adults to process depth information. In four psychophysical conditions, younger and older observers made motion and depth judgments about stationary or translating random-dot stimuli. Stimulus presentations in all four psychophysical conditions were followed by a high-contrast pattern mask, and minimum stimulus presentation durations (stimulus-to-mask onset asynchrony, or SOA) were measured. These SOAs reflect the minimum neural processing time required to make motion and motion parallax depth judgments. Pursuit latency was also measured. The results revealed that, after accounting for age-related delays in motion processing and pursuit onset, older and younger adults required similar temporal intervals to combine retinal image motion with an internal pursuit signal for the perception of depth. These results suggest that the mechanism for motion and pursuit integration is not affected by age., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Global motion perception is often used as an index of dorsal visual stream function in neurodevelopmental studies. However, the relationship between global motion perception and visuomotor control, a primary function of the dorsal stream, is unclear. We measured global motion perception (motion coherence threshold; MCT) and performance on standardized measures of motor function in 606 4.5-year-old children born at risk of abnormal neurodevelopment. Visual acuity, stereoacuity and verbal IQ were also assessed. After adjustment for verbal IQ or both visual acuity and stereoacuity, MCT was modestly, but significantly, associated with all components of motor function with the exception of fine motor scores. In a separate analysis, stereoacuity, but not visual acuity, was significantly associated with both gross and fine motor scores. These results indicate that the development of motion perception and stereoacuity are associated with motor function in pre-school children., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

A new illusion is described. Randomly positioned dots moved radially within an imaginary annular window. The dots' motion periodically changed the direction, leading to an alternating percept of expanding and contracting motion. Strikingly, the apparent size of the enclosed circular region shrank during the dots' expanding phases and dilated during the contracting phases. We quantitatively measured the illusion, and found that the presence of energy at the local kinetic edge could not account for the illusion. Besides, we reproduced the illusion on a natural scene background seen from a first-person point of view that moved forward and backward periodically. Blurring the boundaries of motion areas could not reverse the illusion in all subjects. Taken together, our observed illusion is likely induced by optic flow processing with some components of motion contrast. Expanding or contracting dots may induce the self-motion perception of either approaching or leaving way from the circle. These will make the circle appear smaller or larger since its retinal size remains constant., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

We report a series of experiments in which we assess depth discrimination performance in adults and children using a disparity-balanced target configuration to avoid the effects of anticipatory vergence eye movements. In our first study we found that children outperformed adults by a substantial margin, and the adults were consistently near chance. This was surprising given that we initially tested naïve adults to provide a benchmark for the children's data, and all observers met the criterion for stereoacuity. In subsequent experiments we recruited groups of inexperienced adult observers and assessed the role of a wide range of spatial and temporal factors in this apparent deficit. We found that the adult performance remained poor in spite of changes to the stimulus layout, exposure duration, and spatial scale. The only manipulations that improved performance were those that limited the binocular disparity to a single sign. We conclude that these data reflect a form of involuntary disparity pooling that makes it difficult for naïve observers to judge depth from disparity from multiple targets. The absence of this effect in children likely reflects the late maturation of global processes and depth cue integration., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Humans are able to estimate the reflective properties of the surface (albedo) of an object despite the large variability in the reflected light due to shading, illumination and specular reflection. Here we first used a physically based rendering simulation to study how different statistics (i.e. percentiles) based on the luminance distributions of matte and glossy objects predict the overall surface albedo. We found that the brightest parts of matte surfaces are good predictors of the surface albedo. As expected, the brightest parts led to poor performance in glossy surfaces. We then asked human observers to sort four (2 matte and 2 glossy) objects in a virtual scene in terms of their albedo. The brightest parts of matte surfaces highly correlated with human judgments, whereas in glossy surfaces, the highest correlation was achieved by percentiles within the darker half of the objects' luminance distributions. Furthermore, glossy surfaces tend to appear darker than matte ones, and observers are less precise in judging their lightness. We then manipulated different bands of the virtual objects' luminance distributions separately for glossy and matte surfaces. Modulating the brightest parts of the luminance distributions of the glossy surfaces had a limited impact on lightness perception, whereas it clearly influenced the perceived lightness of the matte objects. Our results demonstrate that human observers effectively ignore specular reflections while evaluating the lightness of glossy objects, which results in a bias to perceive glossy objects as darker., (Copyright © 2016. Published by Elsevier Ltd.)

Perceptual constancy refers to the ability to stabilize the representation of an object even though the retinal image of the object undergoes variations. In previous studies, we proposed a General Object Constancy (GOC) hypothesis to demonstrate a common stabilization mechanism for perception of an object's features, such as size, contrast and depth, as the perceived distance varies. In the present study, we report another depth illusion supporting the GOC model. The stimuli comprised pairs of disks moving in a pattern of radial optic flow. Each pair consisted of a white disk positioned upper left to a dark disk, creating a percept of the white disk casting a shadow. As the pairs contracted towards the center of the screen in accordance with motion away from the observer, the two disks in each pair appeared to increase in contrast and separate farther away from each other both in the fronto-parallel plane (angular separation illusion) and in depth (depth separation illusion). While the contrast illusion and the angular separation illusion, which is a variant of the size illusion, replicated our previous findings, the illusion of depth separation revealed a depth constancy phenomenon. We further confirmed that the size and depth perception were related, e.g., the depth separation and the angular separation illusions were highly correlated across observers. Whereas the illusory increase in the angular separation between a disk and its 'shadow' could not be canceled by modulation of depth, decreasing the angular separation could offset the illusory increase in depth separation. The results can be explained by the GOC hypothesis: the visual system uses the same scaling factor to account for contrast, size (angular separation), and depth variations with distance; additionally, the perceived size of the object is used to scale its depth and contrast signals in order to achieve constancy., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Previous research has demonstrated that humans use allocentric information when reaching to remembered visual targets, but most of the studies are limited to 2D space. Here, we study allocentric coding of memorized reach targets in 3D virtual reality. In particular, we investigated the use of allocentric information for memory-guided reaching in depth and the role of binocular and monocular (object size) depth cues for coding object locations in 3D space. To this end, we presented a scene with objects on a table which were located at different distances from the observer and served as reach targets or allocentric cues. After free visual exploration of this scene and a short delay the scene reappeared, but with one object missing (=reach target). In addition, the remaining objects were shifted horizontally or in depth. When objects were shifted in depth, we also independently manipulated object size by either magnifying or reducing their size. After the scene vanished, participants reached to the remembered target location on the blank table. Reaching endpoints deviated systematically in the direction of object shifts, similar to our previous results from 2D presentations. This deviation was stronger for object shifts in depth than in the horizontal plane and independent of observer-target-distance. Reaching endpoints systematically varied with changes in object size. Our results suggest that allocentric information is used for coding targets for memory-guided reaching in depth. Thereby, retinal disparity and vergence as well as object size provide important binocular and monocular depth cues., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

The contribution of binocular vision to the performance of reaching and grasping movements has been examined previously using single reach-to-grasp movements. However, most of our daily activities consist of more complex action sequences, which require precise temporal linking between the gaze behaviour and manual action phases. Many previous studies found a stereotypical hand-eye coordination pattern, such that the eyes move prior to the reach initiation. Moving the eyes to the target object provides information about its features and location, which can facilitate the predictive control of reaching and grasping. This temporal coordination pattern has been established for the performance of sequential movements performed during binocular viewing. Here we manipulated viewing condition and examined the temporal hand-eye coordination pattern during the performance of a sequential reaching, grasping, and placement task. Fifteen participants were tested on a sequencing task while eye and hand movements were recorded binocularly using a video-based eyetracker and a motion capture system. Our results showed that monocular viewing disrupted the temporal coordination between the eyes and the hand during the place-to-reach transition phase. Specifically, the gaze shift was delayed during monocular compared to binocular viewing. The shift in gaze behaviour may be due to increased uncertainty associated with the performance of the placement task because of increased vergence error during monocular viewing, which was evident in all participants. These findings provide insight into the role of binocular vision in predictive control of sequential reaching and grasping movements., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

A fundamental aspect of human visual perception is the ability to recognize and locate objects in the environment. Importantly, our environment is predominantly three-dimensional (3D), but while there is considerable research exploring the binding of object features and location, it is unknown how depth information interacts with features in the object binding process. A recent paradigm called the spatial congruency bias demonstrated that 2D location is fundamentally bound to object features, such that irrelevant location information biases judgments of object features, but irrelevant feature information does not bias judgments of location or other features. Here, using the spatial congruency bias paradigm, we asked whether depth is processed as another type of location, or more like other features. We initially found that depth cued by binocular disparity biased judgments of object color. However, this result seemed to be driven more by the disparity differences than the depth percept: Depth cued by occlusion and size did not bias color judgments, whereas vertical disparity information (with no depth percept) did bias color judgments. Our results suggest that despite the 3D nature of our visual environment, only 2D location information - not position-in-depth - seems to be automatically bound to object features, with depth information processed more similarly to other features than to 2D location., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

This study, which was influenced a lot by Gestalt ideas, extends our prior work on the role of a priori constraints in the veridical perception of 3D shapes to the perception of 3D scenes. Our experiments tested how human subjects perceive the layout of a naturally-illuminated indoor scene that contains common symmetrical 3D objects standing on a horizontal floor. In one task, the subject was asked to draw a top view of a scene that was viewed either monocularly or binocularly. The top views the subjects reconstructed were configured accurately except for their overall size. These size errors varied from trial to trial, and were shown most-likely to result from the presence of a response bias. There was little, if any, evidence of systematic distortions of the subjects' perceived visual space, the kind of distortions that have been reported in numerous experiments run under very unnatural conditions. This shown, we proceeded to use Foley's (Vision Research 12 (1972) 323-332) isosceles right triangle experiment to test the intrinsic geometry of visual space directly. This was done with natural viewing, with the impoverished viewing conditions Foley had used, as well as with a number of intermediate viewing conditions. Our subjects produced very accurate triangles when the viewing conditions were natural, but their performance deteriorated systematically as the viewing conditions were progressively impoverished. Their perception of visual space became more compressed as their natural visual environment was degraded. Once this was shown, we developed a computational model that emulated the most salient features of our psychophysical results. We concluded that human observers see 3D scenes veridically when they view natural 3D objects within natural 3D environments., (Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.)

Investigations of the relationship between binocular disparity and suprathreshold depth magnitude percepts have used a variety of tasks, stimuli, and methods. Collectively, the results confirm that depth percepts increase with increasing disparity, but there are large differences in how well the estimates correspond to geometric predictions. To evaluate the source of these differences, we assessed depth magnitude percepts for simple stereoscopic stimuli, using both intra- and cross-modal estimation methods, and a large range of test disparities for both experienced and inexperienced observers. Our results confirm that there is a proportional relationship between perceived depth and binocular disparity; this relationship is not impacted by the measurement method. However, observers with minimal prior experience showed strong systematic biases in depth estimation, which resulted in large overestimates at small disparities and substantial underestimates at large disparities. By comparison, experienced observers' depth judgements were much closer to geometric predictions. In subsequent studies we show that unpracticed observers' depth estimates are improved by removing conflicting depth cues, and the observed biases are eliminated when they view physical targets. We conclude that differences in the depth magnitude estimates as a function of disparity in the existing literature are likely due to observers' experience with stereoscopic display systems in which binocular disparity is manipulated while other depth cues are held constant., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

The historical but questionable size-distance invariance hypothesis (SDIH) features computation over geometric, oculomotor, and binocular cues and the coupling of percepts-perceived size, S', is mediated by perceived distance, D'. A contemporary non-mediational hypothesis holds that S' and D' are specific to distinct optical variables. We report two experiments with an optical tunnel, an arrangement of alternating black and white concentric rings, that allows systematic manipulation of the optic array at a point of observation while controlling a variety of size and depth cues. Participants viewed targets of different sizes at different distances monocularly, reporting S' and D' via magnitude production. In Experiment 1, the target was either placed in a continuous tunnel (extending 164cm) or in a tunnel that truncated at the target's location. Experiment 2 included a third tunnel, one that was truncated with a flat depiction of the posterior surface structure that would have been visible in the continuous tunnel. In both experiments, S' decreased with D but D' was unaffected by S. Partial correlation analyses showed that the relationship between S' and D' was not significant when the contributions of other variables were removed. Importantly, S' and D' were affected differently by manipulations of the optical tunnel's continuity while computationally obvious visual cues were controlled. These outcomes suggest that D' is not a mediator of S'. Rather S' and D' are independently determined with correlated but different optical bases, results that support the direct model., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

An observer moving through the world must be able to identify and locate moving objects in the scene. In principle, one could accomplish this task by detecting object images moving at a different angle or speed than the images of other items in the optic flow field. While angle of motion provides an unambiguous cue that an object is moving relative to other items in the scene, a difference in speed could be due to a difference in the depth of the objects and thus is an ambiguous cue. We tested whether the addition of information about the distance of objects from the observer, in the form of monocular depth cues, aided detection of moving objects. We found that thresholds for detection of object motion decreased as we increased the number of depth cues available to the observer., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Both the upper and lower disparity limits for stereopsis vary with the size of the targets. Recently, Tsirlin, Wilcox, and Allison (2012) suggested that perceived depth magnitude from stereopsis might also depend on the vertical extent of a stimulus. To test this hypothesis we compared apparent depth in small discs to depth in long bars with equivalent width and disparity. We used three estimation techniques: a virtual ruler, a touch-sensor (for haptic estimates) and a disparity probe. We found that depth estimates were significantly larger for the bar stimuli than for the disc stimuli for all methods of estimation and different configurations. In a second experiment, we measured perceived depth as a function of the height of the bar and the radius of the disc. Perceived depth increased with increasing bar height and disc radius suggesting that disparity is integrated along the vertical edges. We discuss size-disparity correlation and inter-neural excitatory connections as potential mechanisms that could account for these results., (Copyright © 2016 Elsevier Ltd. All rights reserved.)

Most models of visual saliency operate on two-dimensional images, using elementary image features such as intensity, color, or orientation. The human visual system, however, needs to function in complex three-dimensional environments, where depth information is often available and may be used to guide the bottom-up attentional selection process. In this report we extend a model of proto-object based saliency to include depth information and evaluate its performance on three separate three-dimensional eye tracking datasets. Our results show that the additional depth information provides a small, but statistically significant, improvement in the model's ability to predict perceptual saliency (eye fixations) in natural scenes. The computational mechanisms of our model have direct neural correlates, and our results provide further evidence that proto-objects help to establish perceptual organization of the scene., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Blur is a useful cue for depth. Natural images contain objects at a range of depths whose depth can be signaled by their perceived blur. Here, to evaluate the usefulness of blur as a depth cue, we estimate the number blur levels that observers can perceive simultaneously. To estimate this value, observers discriminated and classified dead leaves patterns that contained a controlled distribution of blur levels but are more complex or naturalistic than stimuli typically used in blur research. We used a 2-IFC discrimination task, in which observers reported the interval that contained more blur levels and a classification task, in which observers reported the number of perceived blur levels. In both tasks, observers could not discriminate or classify more than four levels of blur in the stimulus reliably. In isolation from other cues, blur may provide only a coarse cue to depth and add limited depth information when present in natural scenes with complex distributions of blur and multiple depth cues., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

We investigated whether specular highlights facilitate the perception of shape from shading in a search paradigm and how highlights interact with shading to facilitate this perception. Our results indicated that stimuli containing highlights led to shorter searching time with the dependence on the light source direction (top lights make searching faster), suggesting that highlights indeed facilitate shape-from-shading processing. To examine how highlight processing interacts with shading processing, we tested unnatural stimuli for which the lighting directions for shading and highlights were inconsistent. The results indicated that unnatural highlights (bright spots) placed in a direction inconsistent with the shading either decrease or do not alter searching time. This suggests that highlights may facilitate, and not suppress, shading processing. With more physically plausible highlights generated from image-based lighting, we also observed facilitation with consistent highlights, but no change with inconsistent highlights. Finally, we examined whether highlights indeed work to facilitate depth perception in a discrimination task. The results showed that correct discrimination of depth increases when highlights are added to shading even when their lighting directions are inconsistent. These results indicate that specular highlights facilitate shading processing, and do not suppress it even when the highlights are placed in a direction inconsistent with shading. The results also elucidate the lighting constraints of the visual system., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

The perception of unambiguous depth from motion parallax arises from the neural integration of retinal image motion and extra-retinal eye movement signals. It is only recently that these parameters have been articulated in the form of the motion/pursuit ratio. In the current study, we explored the lower limits of the parameter space in which observers could accurately perform near/far relative depth-sign discriminations for a translating random-dot stimulus. Stationary observers pursued a translating random dot stimulus containing relative image motion. Their task was to indicate the location of the peak in an approximate square-wave stimulus. We measured thresholds for depth from motion parallax, quantified as motion/pursuit ratios, as well as lower motion thresholds and pursuit accuracy. Depth thresholds were relatively stable at pursuit velocities 5-20 deg/s, and increased at lower and higher velocities. The pattern of results indicates that minimum motion/pursuit ratios are limited by motion and pursuit signals, both independently and in combination with each other. At low and high pursuit velocities, depth thresholds were limited by inaccurate pursuit signals. At moderate pursuit velocities, depth thresholds were limited by motion signals., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Global motion processing depends on a network of brain regions that includes extrastriate area V5 in the dorsal visual stream. For this reason, psychophysical measures of global motion perception have been used to provide a behavioral measure of dorsal stream function. This approach assumes that global motion is relatively independent of visual functions that arise earlier in the visual processing hierarchy such as contrast sensitivity and visual acuity. We tested this assumption by assessing the relationships between global motion perception, contrast sensitivity for coherent motion direction discrimination (henceforth referred to as contrast sensitivity) and habitual visual acuity in a large group of 4.5-year-old children (n=117). The children were born at risk of abnormal neurodevelopment because of prenatal drug exposure or risk factors for neonatal hypoglycemia. Motion coherence thresholds, a measure of global motion perception, were assessed using random dot kinematograms. The contrast of the stimuli was fixed at 100% and coherence was varied. Contrast sensitivity was measured using the same stimuli by fixing motion coherence at 100% and varying dot contrast. Stereoacuity was also measured. Motion coherence thresholds were not correlated with contrast sensitivity or visual acuity. However, lower (better) motion coherence thresholds were correlated with finer stereoacuity (ρ=0.38, p=0.004). Contrast sensitivity and visual acuity were also correlated (ρ=-0.26, p=0.004) with each other. These results indicate that global motion perception for high contrast stimuli is independent of contrast sensitivity and visual acuity and can be used to assess motion integration mechanisms in children., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Previous studies have employed different experimental approaches to enhance visual function in adults with amblyopia including perceptual learning, videogame play, and dichoptic training. Here, we evaluated the efficacy of a novel dichoptic action videogame combining all three approaches. This experimental intervention was compared to a conventional, yet unstudied method of supervised occlusion while watching movies. Adults with unilateral amblyopia were assigned to either play the dichoptic action game (n=23; 'game' group), or to watch movies monocularly while the fellow eye was patched (n=15; 'movies' group) for a total of 40hours. Following training, visual acuity (VA) improved on average by ≈0.14logMAR (≈28%) in the game group, with improvements noted in both anisometropic and strabismic patients. This improvement is similar to that obtained following perceptual learning, video game play or dichoptic training. Surprisingly, patients with anisometropic amblyopia in the movies group showed similar improvement, revealing a greater impact of supervised occlusion in adults than typically thought. Stereoacuity, reading speed, and contrast sensitivity improved more for game group participants compared with movies group participants. Most improvements were largely retained following a 2-month no-contact period. This novel video game, which combines action gaming, perceptual learning and dichoptic presentation, results in VA improvements equivalent to those previously documented with each of these techniques alone. Our game intervention led to greater improvement than control training in a variety of visual functions, thus suggesting that this approach has promise for the treatment of adult amblyopia., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Amblyopia is a neuro-developmental disorder of the visual cortex that arises from abnormal visual experience early in life. Amblyopia is clinically important because it is a major cause of vision loss in infants and young children. Amblyopia is also of basic interest because it reflects the neural impairment that occurs when normal visual development is disrupted. Amblyopia provides an ideal model for understanding when and how brain plasticity may be harnessed for recovery of function. Over the past two decades there has been a rekindling of interest in developing more effective methods for treating amblyopia, and for extending the treatment beyond the critical period, as exemplified by new clinical trials and new basic research studies. The focus of this review is on stereopsis and its potential for recovery. Impaired stereoscopic depth perception is the most common deficit associated with amblyopia under ordinary (binocular) viewing conditions (Webber & Wood, 2005). Our review of the extant literature suggests that this impairment may have a substantial impact on visuomotor tasks, difficulties in playing sports in children and locomoting safely in older adults. Furthermore, impaired stereopsis may also limit career options for amblyopes. Finally, stereopsis is more impacted in strabismic than in anisometropic amblyopia. Our review of the various approaches to treating amblyopia (patching, perceptual learning, videogames) suggests that there are several promising new approaches to recovering stereopsis in both anisometropic and strabismic amblyopes. However, recovery of stereoacuity may require more active treatment in strabismic than in anisometropic amblyopia. Individuals with strabismic amblyopia have a very low probability of improvement with monocular training; however they fare better with dichoptic training than with monocular training, and even better with direct stereo training., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Dichoptic training is designed to promote binocular vision in patients with amblyopia. Initial studies have found that the training effects transfer to both binocular (stereopsis) and monocular (recognition acuity) visual functions. The aim of this study was to assess whether dichoptic training effects also transfer to contrast sensitivity (CS) in adults with amblyopia. We analyzed CS data from 30 adults who had taken part in one of two previous dichoptic training studies and assessed whether the changes in CS exceeded the 95% confidence intervals for change based on test-retest data from a separate group of observers with amblyopia. CS was measured using Gabor patches (0.5, 3 and 10cpd) before and after 10days of dichoptic training. Training was delivered using a dichoptic video game viewed through video goggles (n=15) or on an iPod touch equipped with a lenticular overlay screen (n=15). In the iPod touch study, training was combined with anodal transcranial direct current stimulation of the visual cortex. We found that dichoptic training significantly improved CS across all spatial frequencies tested for both groups. These results suggest that dichoptic training modifies the sensitivity of the neural systems that underpin monocular CS., (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Global stereopsis results from the lateral displacement of distributed textured elements between the eyes. In this study, we investigate how the key parameters of the disparity sensitivity function such as its peak sensitivity and spatial bandwidth are distributed across a pool of normal observers and how large the individual differences are. For this purpose, we adapted the quick Contrast Sensitivity Function (qCSF, Lesmes et al., 2010) to the quick Disparity Sensitivity Function (qDSF). We show that this new method is accurate and allows a rapid measurement of disparity sensitivity for a range of different disparity spatial frequencies. Our results confirm that there is a greater variability in human disparity sensitivity tuning compared to other common visual features, for example, 1st or 2nd order contrast sensitivity., (Copyright © 2015 Elsevier Ltd. All rights reserved.)