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Your search keyword '"Iwabuchi, R."' showing total 2 results
Start Over Author "Iwabuchi, R." Publisher elsevier science ltd
2 results on '"Iwabuchi, R."'

1. Synthesis of a novel inhibitor against MRSA and VRE: preparation from zerumbone ring opening material showing histidine-kinase inhibition.

Author

Kitayama T, Iwabuchi R, Minagawa S, Sawada S, Okumura R, Hoshino K, Cappiello J, and Utsumi R

Subjects
Bacillus subtilis enzymology, Histidine Kinase, Microbial Sensitivity Tests, Phosphorylation, Staphylococcus aureus enzymology, Tryptophan analogs & derivatives, Tryptophan pharmacology, Enterococcus faecalis drug effects, Methicillin Resistance drug effects, Protein Kinases drug effects, Sesquiterpenes chemical synthesis, Sesquiterpenes pharmacology, Staphylococcus aureus drug effects
Abstract

Zerumbone ring-opening derivative 2 inhibited autophosphorylation of the essential histidine protein kinase (HPK), YycG, existing in Bacillus subtilis constituting a two-component system (TCS). However, it did not inhibit drug-resistant bacterium such as MRSA and VRE. Tryptophan derivative 34 also could be regulated by a TCS system like 2. In addition, 34 showed good inhibition against MRSA and VRE.

Published
2007
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2. Unprecedented olefin-dependent histidine-kinase inhibitory of zerumbone ring-opening material.

Author

Kitayama T, Iwabuchi R, Minagawa S, Shiomi F, Cappiello J, Sawada S, Utsumi R, and Okamoto T

Subjects
Alkenes isolation & purification, Histidine Kinase, Protein Kinase Inhibitors isolation & purification, Sesquiterpenes isolation & purification, Stereoisomerism, Alkenes chemistry, Protein Kinase Inhibitors chemistry, Protein Kinases metabolism, Sesquiterpenes chemistry
Abstract

Zerumbone ring-opening derivative, 4 (10E/10Z=3/2), inhibited autophosphorylation of the essential histidine-kinase YycG existing in Bacillus subtilis constituting a two-component system (TCS). Generation of 4E-form could be regulated chemically using the difference from the ring-opening reactivity of the precursor forming of 4 and pure 4E was isolated. The stereoisomer, 4E, showed main inhibition activity of autophosphorylation of YycG (IC(50)=63.5 microM).

Published
2004
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