1. Peptide deformylase inhibitors with activity against respiratory tract pathogens.
- Author
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East SP, Beckett RP, Brookings DC, Clements JM, Doel S, Keavey K, Pain G, Smith HK, Thomas W, Thompson AJ, Todd RS, and Whittaker M
- Subjects
- Amidohydrolases metabolism, Anti-Infective Agents pharmacology, Anti-Infective Agents therapeutic use, Enzyme Inhibitors pharmacology, Enzyme Inhibitors therapeutic use, Haemophilus influenzae drug effects, Haemophilus influenzae enzymology, Microbial Sensitivity Tests statistics & numerical data, Moraxella catarrhalis drug effects, Moraxella catarrhalis enzymology, Streptococcus pneumoniae drug effects, Streptococcus pneumoniae enzymology, Amidohydrolases antagonists & inhibitors, Anti-Infective Agents chemistry, Enzyme Inhibitors chemistry, Respiratory Tract Infections enzymology, Respiratory Tract Infections microbiology
- Abstract
A series of analogues of the peptide deformylase (PDF) inhibitor BB-3497 where the P3' amide bond was replaced with a ketone functionality is described. The in vitro antibacterial profiling of these compounds revealed that they demonstrate activity against pathogens associated with respiratory tract infections.
- Published
- 2004
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