1. Plasma level of interleukin-18 and complicated course of febrile neutropenia in hematological patients after intensive chemotherapy.
- Author
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Korpelainen S, Hämäläinen S, Vänskä M, Koivula I, Pulkki K, Jantunen E, Juutilainen A, and Purhonen AK
- Subjects
- Adolescent, Adult, Aged, Female, Humans, Leukocyte Count methods, Lymphoma, Non-Hodgkin blood, Male, Middle Aged, Shock, Septic blood, Young Adult, Febrile Neutropenia blood, Hematologic Neoplasms blood, Interleukin-18 blood, Plasma metabolism
- Abstract
In search of a biomarker for complicated course of febrile neutropenia (FN), plasma IL-18 was measured in 92 hematological patients after intensive chemotherapy at the beginning of FN (days 0-3). Complicated course was defined as blood culture positivity or septic shock. IL-18 varied according to background hematological malignancy and showed an inverse correlation with leukocyte count. IL-18 was not associated with complicated course of FN, defined as blood culture positivity or septic shock, in the whole study group, but an association was observed on d1 and d2 after the onset of FN in the subgroup of autologous stem cell transplant recipients with non-Hodgkin lymphoma., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2020. Published by Elsevier Ltd.)
- Published
- 2020
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