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Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such as differentiation, proliferation, migration, and cellular morphology. Leveraging the matrisome to control these and other tissue-specific processes will be key to developing transplantable bioprosthetics. In the ovary, the physical and biological properties of the matrisome have been implicated in controlling the important processes of follicle quiescence and folliculogenesis. This expanding body of knowledge is being applied in conjunction with new manufacturing processes to enable increasingly complex matrisome engineering, moving closer to emulating tissue structure, composition, and subsequent functions which can be applied to a variety of tissue engineering applications., Competing Interests: Declaration of Interests A.J. is a co-founder and CTO of the company, Dimension Inx., and has ownership and other financial interests in this company. Dimension Inx. did not influence the contents of this article. The other authors declare no conflicts of interest., (Copyright © 2021 Elsevier Ltd. All rights reserved.)