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Although regional differences in lung cancer mortality are likely to be attributable to regional differences in tobacco smoking, studies in various countries found only weak relationships. This paper aimed at explaining regional differences in lung cancer mortality in the Netherlands. In a first step, clues for the role of smoking were obtained from a detailed description of regional mortality differences. These differences were found to be strongly determined by cohort effects: they vary between birth cohorts, and have been stable for over 30 years. Regional mortality differences reflect a diffusion of the lung cancer epidemic from high-income regions to low-income regions. These findings are suggestive of a relationship with regional differences in trends in cigarette smoking. In a second step, by means of multiple regression analysis, mortality differences in 1980-84 were related to available data on cigarette smoking and two other possible risk factors: work in transport and manufacturing industry, and air contamination. The independent variables referred to the 1970s. Positive associations with various smoking measures were found for women, but for men the associations were weak or non-existent. Mortality differences among men 45-64 years were associated with work in transport and manufacturing industry. Strong associations with air contamination were found for men and women 65 years and older. Additional analysis showed that regional differences in lung cancer among old men were strongly associated with smoking in 1930, i.e., half a century before. Changes in the regional pattern of tobacco consumption between 1930 and 1970 explain why smoking in 1970 is not associated with mortality differences in the 1980s. This shows that the explanation of regional lung cancer death rates sometimes has to go far back in time. The strong association with air contamination does not constitute firm evidence of an effect, but should be considered as a stimulus to carry out further analysis on the excess lung cancer mortality in polluted regions.

Lung cancer is one of the most important `avoidable' causes of death world-wide. It is also one in which differences in relation to sex and gender are especially significant. Increasing lung cancer deaths amongst women alongside stable or decreasing deaths amongst men in many countries have substantially altered the male:female ratio in this disease and produced a need to understand differences between men and women in lung cancer risk, and how they relate to sex and gender. This paper reviews research on differences between men and women in lung cancer incidence, mortality and survival, focusing on material which adds to our understanding of the complex differences between each group. This review suggests that the risk of lung cancer may be different for men and women in response to a complex interaction between biological factors such as hormonal difference and gendered factors such as smoking behaviour. In particular women's apparently greater relative risk of lung cancer and the differences between men and women in the risk of specific histological types of lung cancer need to be understood from a perspective in which both biological influences and gender influences are drawn out. Keywords: Gender; Sex differences; Biology; Lung cancer; Smoking