1. Ultrasound targeting of Q-starch/miR-197 complexes for topical treatment of psoriasis.
- Author
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Lifshiz Zimon R, Lerman G, Elharrar E, Meningher T, Barzilai A, Masalha M, Chintakunta R, Hollander E, Goldbart R, Traitel T, Harats M, Sidi Y, Avni D, and Kost J
- Subjects
- Administration, Topical, Animals, Humans, Mice, Mice, SCID, MicroRNAs pharmacokinetics, MicroRNAs therapeutic use, Psoriasis pathology, Receptors, Interleukin analysis, Receptors, Interleukin-17 analysis, Skin Absorption, Swine, Ultrasonic Waves, Drug Carriers chemistry, Drug Delivery Systems methods, MicroRNAs administration & dosage, Psoriasis therapy, Starch chemistry
- Abstract
Psoriasis is a common, worldwide autoinflammatory, incurable skin disease. miR-197 has therapeutic potential for psoriasis since it can down-regulate the expression of both IL-22RA1 and IL-17RA, subunits of the receptors of IL-22 and IL-17, respectively, which are key cytokines in the disease. Although miR-197 has the potential to treat the disease, several inherent physical barrier properties of the skin challenge miRNA's delivery to the target skin cells. In the present study, we evaluated a therapeutic approach that combines the use of ultrasound (US) as a means to enhance skin permeability with quaternized starch (Q-starch) as an miRNA delivery carrier. This resulted in decreased expression of the miR-197 target proteins and in a significant reduction in the psoriatic activity markers. Our results demonstrate the potential of combinations of US and Q-starch/miR-197 complexes for the topical skin treatment of psoriasis., (Copyright © 2018. Published by Elsevier B.V.)
- Published
- 2018
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