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Ten rhesus monkeys were subjected to detailed cerebral and cardiac monitoring over a period of 90 minutes following an experimental gunshot wound. Bradycardia, decreased cardiac output, and decreased pulmonary and systemic blood pressures were observed in the presence of normal preloading (right and left atrial pressures) and afterloading (pulmonary and systemic vascular resistances). Defective cardiac output, autoregulation and cerebrovascular resistance were associated with low perfusion pressures, low cerebral blood flow, and low CMRO2.

Antifibrinolytic drugs and subtotal occulusion of carotid artery have been investigated in a series of 168 patients with recently ruptured intracranial aneursyms. It is concluded that epsilon-aminocaproic acid offers effective treatment, that aggressive hypotensive therapy is dangerous in the severely obtunded patient, and that epsilon-aminocaproic acid plus subtotal carotid occlusion (supplemented by a moderate hypotensive regime) offer the best treatment, in this experience, in the prevention of recurrent hemmorrhages.

Hemispheric cerebral blood flow was measured in 14 patients prior to and after the injection of sodium nitroprusside. The intracarotid method of Xenon was utilized, and flow was calculated by the flow initial technique. With a small reduction in blood pressure during the administration of sodium nitroprusside, the cerebral blood flow fell significantly by 15.9+/- 5.6%.

Demonstration of the exact site of the dural fistulae in cerebrospinal fluid rhinorrhea is difficult. This paper presents a technique for accurate localization of these fistulae, using metrizamide cisternography combined with both hypocycloidal tomography and computed tomography.