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Your search keyword '"Nakatsuji, Hideaki"' showing total 5 results
Start Over Author "Nakatsuji, Hideaki" Publisher elsevier scientific publishers
5 results on '"Nakatsuji, Hideaki"'

1. Three-month treatment with pioglitazone reduces circulating C1q-binding adiponectin complex to total-adiponectin ratio, without changes in body mass index, in people with type 2 diabetes.

Author

Nakatsuji H, Kishida K, Kobayashi H, Funahashi T, and Shimomura I

Subjects
Adiponectin metabolism, Aged, Anti-Inflammatory Agents, Non-Steroidal administration & dosage, Anti-Inflammatory Agents, Non-Steroidal therapeutic use, Body Mass Index, Complement C1q metabolism, Diabetes Mellitus, Type 2 blood, Diabetes Mellitus, Type 2 immunology, Drug Monitoring, Enzyme-Linked Immunosorbent Assay, Female, Humans, Hypoglycemic Agents administration & dosage, Japan, Male, Middle Aged, Molecular Weight, PPAR gamma agonists, Pioglitazone, Thiazolidinediones administration & dosage, Time Factors, Up-Regulation drug effects, Adiponectin blood, Complement C1q analysis, Diabetes Mellitus, Type 2 drug therapy, Down-Regulation drug effects, Hypoglycemic Agents therapeutic use, Thiazolidinediones therapeutic use
Abstract

We measured circulating C1q-binding adiponectin (C1q-APN) levels before and after 3-month treatment with pioglitazone in people with type 2 diabetes. The results indicate 3-month treatment with pioglitazone reduces circulating levels of C1q-APN/total-adiponectin ratio without changes in body mass index., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2013
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2. High serum S100A8/A9 levels and high cardiovascular complication rate in type 2 diabetics with ultrasonographic low carotid plaque density.

Author

Hirata A, Kishida K, Nakatsuji H, Hiuge-Shimizu A, Funahashi T, and Shimomura I

Subjects
Aged, Aged, 80 and over, Atherosclerosis diagnostic imaging, Atherosclerosis pathology, Biomarkers blood, Carotid Artery Diseases diagnostic imaging, Carotid Artery Diseases pathology, Diabetes Mellitus, Type 2 diagnostic imaging, Diabetes Mellitus, Type 2 pathology, Diabetic Angiopathies pathology, Diabetic Nephropathies pathology, Female, Humans, Inflammation diagnostic imaging, Inflammation pathology, Japan, Longitudinal Studies, Male, Middle Aged, Plaque, Atherosclerotic blood, Plaque, Atherosclerotic diagnostic imaging, Smoking, Ultrasonography, Doppler, Color, Atherosclerosis blood, Calgranulin A blood, Calgranulin B blood, Carotid Artery Diseases blood, Diabetes Mellitus, Type 2 blood, Inflammation blood, Plaque, Atherosclerotic pathology
Abstract

Aims: S100A8/A9 complex is an inflammation-associated biomarker, which binds toll-like receptor 4 and was associated with the receptor for advanced glycation end-products. S100A8 and S100A9 were accumulated in atherosclerotic lesions. High serum levels of S100A8/A9 are associated with acute coronary syndrome and atherosclerosis in type 2 diabetes mellitus (T2DM). However, association between serum S100A8/A9 levels and vulnerable plaque remains unclear. The present study investigated the relation between serum S100A8/A9 levels and relative plaque density (RPD) of the carotid artery determined by ultrasonography in T2DM., Methods: The study subjects were 72 consecutive T2DM outpatients (males/females=42/30), who underwent the carotid artery ultrasonography. RPD in the carotid artery was calculated by the formula; RPD=[density of the carotid plaque/density of vessel lumen]. Serum levels of adiponectin and S100A8/A9 were measured., Results: The median RPD was 2.1. Patients with low RPD (≤2.1) were significantly more likely to have metabolic syndrome, nephropathy, coronary artery disease, and peripheral artery disease, and higher levels of S100A8/A9, S100A8/A9-to-adiponectin ratio, and uric acid, compared to those with high RPD (>2.1)., Conclusions: T2DM patients with low RPD had higher prevalence of metabolic syndrome, cardiovascular diseases and higher serum S100A8/A9 levels, compared to those with high RPD., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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3. Metabolic syndrome correlates with polyvascular lesions detected by systemic vascular ultrasonography in Japanese people with type 2 diabetes.

Author

Hirata A, Kishida K, Nakatsuji H, Hiuge-Shimizu A, Funahashi T, and Shimomura I

Subjects
Adult, Aged, Aged, 80 and over, Atherosclerosis pathology, Female, Humans, Male, Metabolic Syndrome pathology, Middle Aged, Ultrasonography, Atherosclerosis diagnostic imaging, Diabetes Mellitus, Type 2 diagnostic imaging, Diabetes Mellitus, Type 2 pathology, Metabolic Syndrome diagnostic imaging
Abstract

Atherosclerosis is a systemic disease of blood vessels. We investigated clinical characteristics of Japanese type 2 diabetic patients with polyvascular lesions detected by systemic vascular ultrasonography. The results showed that the metabolic syndrome correlated with polyvascular lesions detected by systemic vascular ultrasonography in Japanese type 2 diabetics., (Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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4. Three-month treatment with pioglitazone reduces circulating levels of S100A8/A9 (MRP8/14) complex, a biomarker of inflammation, without changes in body mass index, in type 2 diabetics with abdominal obesity.

Author

Nakatsuji H, Kishida K, Funahashi T, and Shimomura I

Subjects
Aged, Biomarkers blood, Body Mass Index, Diabetes Mellitus, Type 2 pathology, Female, Humans, Hypoglycemic Agents, Inflammation drug therapy, Male, Middle Aged, Pioglitazone, Calgranulin A blood, Calgranulin B blood, Diabetes Mellitus, Type 2 drug therapy, Obesity, Abdominal, Thiazolidinediones therapeutic use
Abstract

We measured circulating S100A8/A9 (MRP8/14) complex levels before and after 3-month treatment with pioglitazone in type 2 diabetic patients. The results showed that pioglitazone reduced circulating S100A8/A9 complex levels, without changing body mass index, in type 2 diabetic patients with abdominal obesity., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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5. Carotid intima-media thickness, but not visceral fat area or adiponectin, correlates with intracoronary stenosis detected by multislice computed tomography in people with type 2 diabetes and hypertension.

Author

Nakanishi-Minami T, Kishida K, Nakagawa Y, Nakatsuji H, Kuroda Y, Okauchi Y, Yamasaki K, Nojima Y, Tsujii K, Kumada M, Tachibana K, Nakamura T, Sumitsuji S, Funahashi T, and Shimomura I

Subjects
Aged, Coronary Stenosis physiopathology, Diabetes Mellitus, Type 2 diagnostic imaging, Female, Humans, Hypertension diagnostic imaging, Intra-Abdominal Fat diagnostic imaging, Male, Middle Aged, Multidetector Computed Tomography, Adiponectin blood, Carotid Intima-Media Thickness, Coronary Stenosis complications, Coronary Stenosis diagnostic imaging, Diabetes Mellitus, Type 2 complications, Hypertension complications, Intra-Abdominal Fat physiopathology
Abstract

We investigated the relationship between intracoronary stenosis detected by multislice computed tomography and various clinical parameters in type 2 diabetic patients with hypertension treated with candesartan (n=42). The results showed that carotid intima-media thickness, but not visceral fat area or adiponectin, correlated significantly with intracoronary stenosis (p<0.05)., (Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.)

Published
2012
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