1. Results of radiotherapy in patients with stage I orbital non-Hodgkin's lymphoma.
- Author
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Letschert JG, González González D, Oskam J, Koornneef L, van Dijk JD, Boukes R, Bras J, van Heerde P, and Bartelink H
- Subjects
- Dose-Response Relationship, Radiation, Eye radiation effects, Humans, Lymphoma, Non-Hodgkin diagnostic imaging, Lymphoma, Non-Hodgkin pathology, Neoplasm Staging, Orbit radiation effects, Orbital Neoplasms diagnostic imaging, Orbital Neoplasms pathology, Tomography, X-Ray Computed, Lymphoma, Non-Hodgkin radiotherapy, Orbital Neoplasms radiotherapy
- Abstract
This paper describes the results of radiotherapy in early stage orbital non-Hodgkin's lymphoma. From 1970 to 1985, 33 orbital localizations in 30 patients were treated. The total dose applied ranged from 21 to 57 Gy (2 Gy per fraction), two-thirds of all patients received a dose of 40 Gy. The complete-response rate was 94% and the 10 years actuarial survival was 90%; no significant difference in survival was observed between patients with low grade or intermediate grade lymphoma. No local recurrence was detected during follow up and 20% of the patients developed generalized disease. Two optic nerve neuropathies and three retinopathies were observed in five patients, four of these occurred at a dose level of less than 43 Gy. Keratitis occurred in 58% of the patients treated, a sicca syndrome in 30% and cataract of different grades in 58% of the patients treated. Although local control was excellent, severe complications were observed in 13% of the patients who received a dose of less than 43 Gy.
- Published
- 1991
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