1. Effect of the aqueous extract of Senecio biafrae (Oliv. & Hiern) J. Moore on some fertility parameters in immature female rat.
- Author
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Lienou LL, Telefo PB, Njimou JR, Nangue C, Bayala BR, Goka SC, Biapa P, Yemele MD, Donfack NJ, Mbemya JT, Tagne SR, and Rodrigues AP
- Subjects
- Animals, Blood Proteins metabolism, Body Weight drug effects, Estradiol blood, Female, Follicle Stimulating Hormone blood, Luteinizing Hormone blood, Organ Size drug effects, Ovary anatomy & histology, Ovary drug effects, Phenols analysis, Plant Extracts chemistry, Progesterone blood, Rats, Wistar, Sexual Maturation drug effects, Uterus anatomy & histology, Uterus drug effects, Fertility drug effects, Plant Extracts pharmacology, Senecio
- Abstract
Ethnopharmacological Relevance: Senecio biafrae is a plant from the huge family of Asteraceae used in the African pharmacopoeia for the treatment of many ailments among which is infertility., Material and Methods: The aqueous extract, which was primarily subjected to polyphenol analysis, has been administered to immature female rats for 20 days at 8, 32, 64 and 128 mg/kg of body weight. The day following the treatment, the animals were sacrificed; their serum, ovary and uterus were retained respectively for reproductive hormones, ovarian and uterine proteins, and ovarian cholesterol assays., Results: Light body weight gain variation of treated animals was observed during the experimental period. A significant increase (p ˂ 0.05) in serum estradiol and proteins as well as in uterine weight (p ˂ 0.01) of all Senecio biafrae treated animals was noted. No significant variation was noticed in the ovarian weight and follicle numbers., Conclusion: The various biochemical and physiological parameters of fertility were significantly improved with the aqueous extract of Senecio biafrae, thus attesting some of its traditional usage., (Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.)
- Published
- 2015
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