1. Photodynamic therapy with aluminum-chloro-phthalocyanine induces necrosis and vascular damage in mice tongue tumors.
- Author
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Longo JP, Lozzi SP, Simioni AR, Morais PC, Tedesco AC, and Azevedo RB
- Subjects
- Animals, Indoles administration & dosage, Indoles adverse effects, Light, Mice, Necrosis chemically induced, Organometallic Compounds administration & dosage, Organometallic Compounds adverse effects, Temperature, Tongue blood supply, Tongue drug effects, Tongue pathology, Tongue radiation effects, Tongue Neoplasms drug therapy, Indoles therapeutic use, Organometallic Compounds therapeutic use, Photochemotherapy, Tongue Neoplasms blood supply, Tongue Neoplasms pathology
- Abstract
In this paper we describe the efficacy of the liposomal-AlClPc (aluminum-chloro-phthalocyanine) formulation in PDT study against Ehrlich tumor cells proliferation in immunocompetent swiss mice tongue. Experiments were conduced in sixteen tumor induced mice that were divided in three control groups: (1) tumor without treatment; (2) tumor with 100J/cm(2) laser (670nm) irradiation; and (3) tumor with AlClPc peritumoral injection; and a PDT experimental group when tumors received AlClPc injection followed by tumor irradiation. Control groups present similar macroscopically and histological patterns after treatments, while PDT treatment induced 90% of Ehrlich tumor necrosis after 24h of one single application, showing the efficacy of liposome-AlClPc (aluminum-chloro-phthalocyanine) mediated PDT on the treatment of oral cancer.
- Published
- 2009
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