1. Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activity.
- Author
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Feresin GE, Tapia A, Gimenez A, Ravelo AG, Zacchino S, Sortino M, and Schmeda-Hirschmann G
- Subjects
- Anti-Bacterial Agents chemistry, Anti-Bacterial Agents isolation & purification, Antifungal Agents chemistry, Antifungal Agents isolation & purification, Argentina, Bacteria drug effects, Coumaric Acids chemistry, Coumaric Acids isolation & purification, Coumaric Acids pharmacology, Diterpenes chemistry, Diterpenes isolation & purification, Diterpenes pharmacology, Flavonoids chemistry, Flavonoids isolation & purification, Flavonoids pharmacokinetics, Fungi drug effects, Medicine, Traditional, Plant Components, Aerial, Resins, Plant chemistry, Resins, Plant isolation & purification, Anti-Bacterial Agents pharmacology, Antifungal Agents pharmacology, Baccharis, Resins, Plant pharmacology
- Abstract
The resinous exudate of Baccharis grisebachii which is used to treat ulcers, burns, and skin sores in Argentina showed activity towards dermatophytes and bacteria. Two diterpenes, eight p-coumaric acid derivatives, and two flavones were isolated from the exudate and the structures elucidated by spectroscopic methods. 3-Prenyl-p-coumaric acid and 3,5-diprenyl-p-coumaric acid were active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 50 and 100-125 microg/ml, respectively. The diterpene labda-7,13E-dien-2beta,15-diol was active towards Epidermophyton floccosum and Trichophyton rubrum with MICs of 12.5 microg/ml while the MIC against Microsporum canis and Trichophyton mentagrophytes was 25 microg/ml. The diterpene was also active towards Microsporum gypseum with a MIC of 50 microg/ml, and showed inhibition in both Staphylococcus aureus (methicilline resistant and sensible strains) with MICs of 125 microg/ml. The results support the use of Baccharis grisebachii in Argentinian traditional medicine.
- Published
- 2003
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